ArticleJournal of molecular neuroscience : MN2010
Searching for new genetic risk factors for neuropsychiatric disorders in expression databases.
Article in Journal of molecular neuroscience : MN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Investigating the shared genetic architecture between frailty and insomnia.Frontiers in aging neuroscience · 2024Article
- Retinal Nerve Fiber Layer Thickness Measurement by Spectral-Domain Optical Coherence Tomography in Patients with Major Depressive Disorder.Noro psikiyatri arsivi · 2017Article
- Chronic depression as a model disease for cerebral aging.Dialogues in clinical neuroscience · 2013Review
- Neuroinflammation, neurodegeneration, and depression.Neurotoxicity research · 2013Review
- Searching for new genetic variations in expression databases for the GABAergic and glutamatergic systems.Journal of molecular neuroscience : MN · 2012Article
- Exploring the implications of INDELs in neuropsychiatric genetics: challenges and perspectives.Journal of molecular neuroscience : MN · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic variations might contribute to differences in protein activities and gene expression levels observed in complex genetic traits, like neuropsychiatric disease. This finding motivated the development of original approaches using expression studies to guide the finding of new genetic variations. We extended this approach to new genes selected from microarrays studies of brain samples of patients with Alzheimer's disease, major depressive disorder, bipolar affective disorder, and sporadic Creutzfeldt-Jakob disease. The CLCbio Workbench Combined version 3.6.2 was initially used to build expression sites tags (ESTs) and mRNA files retrieved, respectively, from the Goldenpath (UCSC) and NCBI databases and latter to perform multiple batches of Smith-Waterman alignments. The total of 438 ESTs sequences were selected after proper stringent parameters were applied to the first set of mismatches. The annotation revealed various classes of variations, most of them deletions ranging from 1 to 10 pb. These deletions were present in coding regions, 5' and 3' UTR regions. Deletions are often associated to major genetic syndromes with dysmorphic features; however, recent studies show that common microdeletions might be highly associated with common neuropsychiatric disorders.
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