ArticleJournal of gastroenterology2010
Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits.
Article in Journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children's Study.BMC medicine · 2026Article
- A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels.Cancer prevention research (Philadelphia, Pa.) · 2025Article
- Daily eating frequency, nighttime fasting duration, and the risk of non-alcoholic fatty liver disease: a cross-sectional study.Nutrition journal · 2025Article
- Frequency and risk factors of metabolic associated fatty liver disease among medical students in Egypt.Scientific reports · 2025Article
- Joint association of sleep quality and physical activity with metabolic dysfunction-associated fatty liver disease: a population-based cross-sectional study in Western China.Nutrition & diabetes · 2024Article
- Review
- Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study.Saudi journal of biological sciences · 2021Article
- Effect of moderate exercises and curcumin on hepatic transcriptional factors associated with lipid metabolism and steatosis in elderly male rat.Research in pharmaceutical sciences · 2021Article
- Article
- Current status, problems, and perspectives of non-alcoholic fatty liver disease research.World journal of gastroenterology · 2019Review
- Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents: 2001-2014.BMC public health · 2018Article
- Targeting nuclear receptors for the treatment of fatty liver disease.Pharmacology & therapeutics · 2017Review
- What is the appropriate strategy for diagnosing NAFLD using ultrasonography in obese children?World journal of pediatrics : WJP · 2017Article
- Association between endotoxemia and histological features of nonalcoholic fatty liver disease.World journal of gastroenterology · 2017Article
- Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority Populations.Digestive diseases and sciences · 2016Review
- Physical Activity Is Prospectively Associated With Adolescent Nonalcoholic Fatty Liver Disease.Journal of pediatric gastroenterology and nutrition · 2016Article
- Article
- Effects of physical activity upon the liver.European journal of applied physiology · 2015Review
- Epidemiology of a fast emerging disease in the Asia-Pacific region: non-alcoholic fatty liver disease.Hepatology international · 2013Article
- Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.Hepatology (Baltimore, Md.) · 2012Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the increase in nonalcoholic fatty liver disease (NAFLD) in Japanese adults, its prevalence in adolescents remains unclear. This prompted us to evaluate the incidence and clinical characteristics of NAFLD among junior high school students.
methodsA population-based cross-sectional study was conducted among students in a single junior high school in Nagano prefecture. Serum alanine aminotransferase (ALT) and gamma-glutamyltransferase (gammaGT) measurements and abdominal ultrasonography were performed in 249 and 288 students in 2004 and 2007, respectively. In the latter survey, student lifestyle habits were also assessed, using questionnaires.
resultsThe prevalence of NAFLD was 4.4% and 4.5% in 2004 and 2007, respectively, which was lower than that of obesity (10.0% and 5.9%). Body mass index and ALT and gammaGT levels increased significantly with hepatic steatosis severity. Multivariate logistic regression analysis demonstrated that the presence of obesity and an ALT level of 30 U/L or more were independent predictors of NAFLD (odds ratio 16.9, P<0.001 and odds ratio 16.6, P=0.001, respectively). The ratios of students commuting to and from school by car and not doing sports outside of school were higher in NAFLD students compared with non-NAFLD ones. Such tendencies were observed independently of the presence of obesity. Additionally, one obese student with severe steatosis and liver dysfunction was diagnosed as having nonalcoholic steatohepatitis (NASH).
conclusionsApproximately 4% of junior high school students had NAFLD that was primarily associated with obesity and reduced daily physical activity. Serum ALT measurement during school check-ups is recommended for the early detection of young adolescent NAFLD/NASH.
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