ArticleJournal of neurology2010
Living with multiple sclerosis: longitudinal changes in employment and the importance of symptom management.
Article in Journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Adrenocorticotropic Hormone (ACTHAR Gel) on Recovery From Cognitive Relapses in Multiple Sclerosis
Real-Life Outcomes of Multiple Sclerosis Treatment With Rebif on Employment Status, Quality of Life and Cognition: a Pilot Study
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 236 citations in OpenAlex.
- Towards conceptual convergence: A systematic review of psychological resilience in family caregivers of persons living with chronic neurological conditions.Health expectations : an international journal of public participation in health care and health policy · 2022Pooled it
- The association of fatigue, pain, depression and anxiety with work and activity impairment in immune mediated inflammatory diseases.PloS one · 2018Trial
- The Multiple Sclerosis-Fatigue Self- Efficacy (MS-FSE) scale: initial validation.Clinical rehabilitation · 2015Trial
- Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss.Annals of clinical and translational neurology · 2026Article
- Age-impaired remyelination is associated with dysregulated microglial transitions.Nature communications · 2025Article
- A Comprehensive and Structured Follow-Up for Persons With Multiple Sclerosis (CoreDISTparticipation) to Optimize Physical Functions, Health, and Employment: Protocol for a Prospective, Single-Blinded Randomized Controlled Trial and Health Economic Evaluation.JMIR research protocols · 2025Article
- Article
- Quality of life and access to treatment for patients with multiple sclerosis during economic crisis: the Lebanese experience.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Identifying key determinants of work-related difficulties in multiple sclerosis: integrating clinical measures and socio-occupational factors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Work Difficulties in People with Multiple Sclerosis.Journal of occupational rehabilitation · 2024Article
- Explaining the burden of cultural factors on MS disease: a qualitative study of the experiences of women with multiple sclerosis.BMC women's health · 2024Article
- Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis.IBRO neuroscience reports · 2024Article
- Article
- The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multiple Methods Study.International journal of MS care · 2024Article
- Views of Specialist Clinicians and People With Multiple Sclerosis on Upper Limb Impairment and the Potential Role of Virtual Reality in the Rehabilitation of the Upper Limb in Multiple Sclerosis: Focus Group Study.JMIR serious games · 2024Article
- A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohort.Scientific reports · 2023Article
- Dual-task difficulties as a risk factor for unemployment in people with multiple sclerosis.Brain and behavior · 2023Article
- Cost-consequence analysis of ofatumumab for the treatment of relapsing-remitting multiple sclerosis in Canada.Journal of comparative effectiveness research · 2023Article
- Long-term follow-up of patients with relapsing multiple sclerosis from the CLARITY/CLARITY Extension cohort of CLASSIC-MS: An ambispective study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Effects of repetitive twice-weekly transcranial direct current stimulations on fatigue and fatigability in people with multiple sclerosis.Scientific reports · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
People with multiple sclerosis (MS) tend to have lower participation in paid employment compared to those with other chronic diseases. In two large-sample, self-report surveys of MS patients performed 4 years apart, employment rates were measured both cross-sectionally and longitudinally. The reasons for employment loss and perceived risk of future employment loss were also assessed. A total of 1,135 patients responded to the first survey, 1,329 to the second, and 667 to both. Longitudinal loss of employment was 5.4% over the 4 years 2003-2007, a period of relative national economic prosperity. By 2007, 56% of MS patients had lost employment due to MS and 64% were not in the paid labour force. Regression analysis indicated that men were more likely than women to leave their employment because of their MS, and older people were more likely than younger ones to do so. Level of occupational skill using Australian Bureau of Statistics categorisation was not predictive of maintaining or losing employment. The main reasons reported by people with MS for their loss of employment involved the ineffective management of symptoms of MS in the workplace, rather than workplace-related factors including insufficient flexibility of employment conditions or being asked to leave or sacked. The most frequently listed symptoms relating to employment loss, and perceived risk of losing current employment, were fatigue, mobility-related symptoms, arm and hand difficulties, and cognitive deficits. These findings imply that many employees with MS are leaving their planning for effective symptom management, and for appropriate accommodations in the workplace, until such planning is too late to be effective. The potential advantages of early, supported disclosure of diagnosis to employers before MS symptoms become a problem are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.