ArticlePediatric nephrology (Berlin, Germany)2010
Urinary levels of interleukin-6 and interleukin-8 in patients with vesicoureteral reflux and renal parenchymal scar.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Biomarker for renal scarring screening in children with vesicoureteral reflux: a systematic review.Frontiers in pediatrics · 2025Pooled it
- The Utility of Noninvasive Urinary Biomarkers for the Evaluation of Vesicoureteral Reflux in Children.International journal of molecular sciences · 2023Article
- Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects.Journal of clinical medicine · 2023Review
- Serum and Urine Interleukin-6 and Interleukin-8 Levels Do Not Differentiate Acute Pyelonephritis from Lower Urinary Tract Infections in Children.Journal of inflammation research · 2020Article
- Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children.International urology and nephrology · 2019Article
- Urine neutrophil gelatinase-associated lipocalin and other biomarkers in infants with urinary tract infection and in febrile controls.Pediatric nephrology (Berlin, Germany) · 2017Article
- Posterior urethral valve in fetuses: evidence for the role of inflammatory molecules.Pediatric nephrology (Berlin, Germany) · 2017Article
- Dysbiosis of the Urinary Microbiota Associated With Urine Levels of Proinflammatory Chemokine Interleukin-8 in Female Type 2 Diabetic Patients.Frontiers in immunology · 2017Article
- Urinary L-FABP as a marker of vesicoureteral reflux in children: could it also have a protective effect on the kidney?International urology and nephrology · 2017Article
- Urine interleukin-6, interleukin-8 and transforming growth factor β1 in infants with urinary tract infection and asymptomatic bacteriuria.Central-European journal of immunology · 2016Article
- The role of urinary TGF-β₁, TNF-α, IL-6 and microalbuminuria for monitoring therapy in posterior urethral valves.Pediatric nephrology (Berlin, Germany) · 2013Article
- Urinary concentration of cytokines in children with acute pyelonephritis.European journal of pediatrics · 2013Observational
- Cytokines in chronic kidney disease: potential link of MCP-1 and dyslipidemia in glomerular diseases.Pediatric nephrology (Berlin, Germany) · 2013Article
- Interactions between cytokines, congenital anomalies of kidney and urinary tract and chronic kidney disease.Clinical & developmental immunology · 2013Review
- Interleukin-6 and interleukin-8 levels in the urine of children with renal scarring.Pediatric nephrology (Berlin, Germany) · 2012Article
- Early risk factors for neonatal mortality in CAKUT: analysis of 524 affected newborns.Pediatric nephrology (Berlin, Germany) · 2012Article
- Urine IL-8 concentrations in infectious and non-infectious urinary tract conditions.Pediatric nephrology (Berlin, Germany) · 2011Article
- Urinary levels of TGF β-1 and of cytokines in patients with prenatally detected nephrouropathies.Pediatric nephrology (Berlin, Germany) · 2011Article
- Correlation of Urinary Biomarkers (Interleukin-6, Transforming growth factor-β, E-Cadherin, and MCP-1) with Conventional Parameters of Disease Progression in Patients of Posterior Urethral Valves: A Comparative Analysis.Journal of Indian Association of Pediatric SurgeonsArticle
- Utility of Urinary Biomarkers Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as a Marker for Diagnosing the Presence of Renal Scar in Children with Vesicoureteral Reflux (VUR): A Cross-Sectional Study.Journal of Indian Association of Pediatric SurgeonsArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to assess the urine levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) as noninvasive markers of vesicoureteral reflux (VUR) and renal parenchymal scarring (RPS) in children in the absence of a recent urinary tract infection (UTI) episode. Urine concentrations of IL-6 and IL-8 in 114 children aged 1 month to 16 years were evaluated. The children were divided into four groups: group 1, 26 children with VUR and RPS; group 2, 27 children with VUR without RPS; group 3, 34 children with RPS without VUR, group 4, 27 children without VUR and RPS, as the control group. After the first assessment, the children were divided into four larger groups for comparison purposes: group A (groups 1+2), 53 children with VUR; group B (groups 3+4), 61 children without VUR; group C (groups 1+3), 60 children with RPS; group D (groups 2+4), 54 children without RPS. Urinary IL-6 and IL-8 concentrations were determined. To avoid dilution effects and to the standardize samples, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg). The median urine IL-6/creatinine was significantly higher in patients with VUR than in those without VUR (5.72 vs. 3.73). In patients with VUR, there was a significant but rather weak correlation between IL-6/creatinine concentrations and there flux grade (p<0.05, R=0.305). The median urine IL-8/creatinine was significantly higher in patients with RPS than in those without RPS (43.12 vs. 16.36). In patients with RPS, there was a significant but rather weak correlation between IL-8/creatinine concentrations and the renal scar grade (p<0.05, R=0.251). The results of this study provide preliminary evidence that children with VUR have a high urine IL-6 concentration, whereas children with RPS have a high urine IL-8 concentration.
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