ArticleAnnals of hematology2010
T-cell large granular lymphocyte leukemia: an Asian perspective.
Article in Annals of hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Epidemiology of mature T-cell and NK-cell neoplasms: east and west.The Lancet regional health. Western Pacific · 2025Review
- Clinical features and outcomes in large granular lymphocyte leukemia - associated pure red cell aplasia with STAT3 mutation.Annals of hematology · 2025Article
- Large Granular Lymphocytic Leukemia: Clinical Features, Molecular Pathogenesis, Diagnosis and Treatment.Cancers · 2024Review
- Transient Leukemoid Reaction from T-Cell Large Granular Lymphocytes Post Autologous Stem Cell Transplant in a Patient Affected by Hodgkin Lymphoma.Hematology reports · 2023Article
- Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: low mutational burden of STAT3.Scientific reports · 2023Article
- Incidence of acquired pure red cell aplasia: a nationwide epidemiologic analysis with 2 registry databases in Japan.Blood advances · 2022Article
- Clinical characteristics and outcomes of 100 adult patients with pure red cell aplasia.Annals of hematology · 2022Article
- Pathophysiologic Mechanisms And Management Of Large Granular Lymphocytic Leukemia Associated Pure Red Cell Aplasia.OncoTargets and therapy · 2019Article
- FrequentBlood advances · 2018Article
- Response to cyclosporine A and corticosteroids in adult patients with acquired pure red cell aplasia: serial experience at a single center.International journal of hematology · 2018Article
- A screening method with lymphocyte percentage and proportion of granular lymphocytes in the peripheral blood for large granular lymphocyte (LGL) leukemia.International journal of hematology · 2017Article
- Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias.Internal medicine (Tokyo, Japan) · 2017Review
- [CD4⁺/CD8⁻ T- cell large granular lymphocytic leukemia: one case report and literatures reviews].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015Review
- STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia.Cancer science · 2014Article
- STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia.Journal of hematology & oncology · 2013Article
- Clonal lymphoproliferation of T cell large granular lymphocytes with pleomorphic nuclei following mantle cell lymphoma.International journal of hematology · 2013Article
- Small-Sized Clone of T Cells in Multiple Myeloma Patient after Auto-SCT: T-LGL Leukemia Type or Clonal T-Cell Aberration?Case reports in hematology · 2013Article
- Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis.Bone marrow transplantation · 2012Article
- The spectrum of large granular lymphocyte leukemia and Felty's syndrome.Current opinion in hematology · 2011Review
- T-Cell Large Granular Lymphocytic Leukemia Presenting as Isolated Transfusion-Dependent Anemia Without Autoimmune Disease: A Case Report.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most common indication for treatment. Neutropenia was only found in 8/22 (36%) cases, and recurrent infections, the most important clinical problem in Western patients, were not observed. None of our cases presented with rheumatoid arthritis. These clinical features were consistently observed when compared with the 88 other Asian patients. Combined data from our cohort and other Asian cases showed that Asian patients, compared with Western patients, had more frequent anemia (66/110, 60% versus 113/240, 47%; p=0.044), attributable to a much higher incidence of PRCA (52/110, 47% versus 6/143, 4%; p<0.001). However, Western patients presented more frequently than Asian patients with neutropenia (146/235, 62% versus 33/110, 30%; p<0.001) and splenomegaly (99/246, 40% versus 16/110, 15%; p< 0.001). Notably, Western patients were about eight to ten times more likely than Asian patients to have rheumatoid arthritis (73/272, 27% versus 4/106, 4%; p<0.001) and recurrent infections (81/272, 30% versus 3/107, 3%; p<0.001). These clinicopathologic differences have important implications on disease pathogenesis and treatment.
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