ArticlePloS one2010
Genome-wide analyses of gene expression during mouse endochondral ossification.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Article
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- Genes with specificity for expression in the round cell layer of the growth plate are enriched in genomewide association study (GWAS) of human height.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Histone deacetylase 4 deletion results in abnormal chondrocyte hypertrophy and premature ossification from collagen type 2α1‑expressing cells.Molecular medicine reports · 2020Article
- A New Look at Causal Factors of Idiopathic Scoliosis: Altered Expression of Genes Controlling Chondroitin Sulfate Sulfation and Corresponding Changes in Protein Synthesis in Vertebral Body Growth Plates.International journal of medical sciences · 2019Article
- Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions.PLoS genetics · 2018Article
- Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2018Review
- Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone.BMC cell biology · 2016Review
- Early Characterization of Blast-related Heterotopic Ossification in a Rat Model.Clinical orthopaedics and related research · 2015Article
- Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development.BMC developmental biology · 2015Article
- Single-Cell RNA-Seq of Bone Marrow-Derived Mesenchymal Stem Cells Reveals Unique Profiles of Lineage Priming.PloS one · 2015Article
- Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors.The Journal of clinical investigation · 2014Article
- Hindlimb heating increases vascular access of large molecules to murine tibial growth plates measured by in vivo multiphoton imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Potential of human fetal chorionic stem cells for the treatment of osteogenesis imperfecta.Stem cells and development · 2014Article
- GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.The Journal of biological chemistry · 2012Article
- Coculture strategies in bone tissue engineering: the impact of culture conditions on pluripotent stem cell populations.Tissue engineering. Part B, Reviews · 2012Review
- Mouse strain specific gene expression differences for illumina microarray expression profiling in embryos.BMC research notes · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEndochondral ossification is a complex process involving a series of events that are initiated by the establishment of a chondrogenic template and culminate in its replacement through the coordinated activity of osteoblasts, osteoclasts and endothelial cells. Comprehensive analyses of in vivo gene expression profiles during these processes are essential to obtain a complete understanding of the regulatory mechanisms involved. METHODOLOGY/PRINCIPAL
findingsTo address these issues, we completed a microarray screen of three zones derived from manually segmented embryonic mouse tibiae. Classification of genes differentially expressed between each respective zone, functional categorization as well as characterization of gene expression patterns, cytogenetic loci, signaling pathways and functional motifs both confirmed reported data and provided novel insights into endochondral ossification. Parallel comparisons of the microdissected tibiae data set with our previously completed micromass culture screen further corroborated the suitability of micromass cultures for modeling gene expression in chondrocyte development. The micromass culture system demonstrated striking similarities to the in vivo microdissected tibiae screen; however, the micromass system was unable to accurately distinguish gene expression differences in the hypertrophic and mineralized zones of the tibia. CONCLUSIONS/SIGNIFICANCE: These studies allow us to better understand gene expression patterns in the growth plate and endochondral bones and provide an important technical resource for comparison of gene expression in diseased or experimentally-manipulated cartilages. Ultimately, this work will help to define the genomic context in which genes are expressed in long bones and to understand physiological and pathological ossification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.