ArticlePloS one2010
High-field FMRI reveals brain activation patterns underlying saccade execution in the human superior colliculus.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- An fMRI Investigation of Preparatory Set in the Human Cerebral Cortex and Superior Colliculus for Pro- and Anti-Saccades.PloS one · 2016Trial
- The contribution of the koniocellular visual pathway to aversive learning in human visual cortex.Journal of neurophysiology · 2026Article
- Spatial evolution in temporal dynamics of hemodynamic response function in human superior colliculi with ultra-high-resolution MRI at 9.4T.Frontiers in neuroscience · 2026Article
- Structural and functional MRI evidence for significant contribution of precentral gyrus to flexible oculomotor control: evidence from the antisaccade task.Brain structure & function · 2022Article
- Spatially Specific Working Memory Activity in the Human Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Shared variance of oculomotor phenotypes in a large sample of healthy young men.Experimental brain research · 2018Article
- Article
- Superior colliculus resting state networks in post-traumatic stress disorder and its dissociative subtype.Human brain mapping · 2018Article
- Altered functional connectivity of primary visual cortex in late blindness.Neuropsychiatric disease and treatment · 2018Article
- Depth-dependence of visual signals in the human superior colliculus at 9.4 T.Human brain mapping · 2017Article
- The Association Between Eye Movements and Cerebellar Activation in a Verbal Working Memory Task.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Effects of a pretarget distractor on saccade reaction times across space and time in monkeys and humans.Journal of vision · 2016Article
- Activity in the human superior colliculus relating to endogenous saccade preparation and execution.Journal of neurophysiology · 2015Article
- Comparative diffusion tractography of corticostriatal motor pathways reveals differences between humans and macaques.Journal of neurophysiology · 2015Article
- Frontal-subcortical circuits involved in reactive control and monitoring of gaze.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Parietal connectivity mediates multisensory facilitation.NeuroImage · 2013Article
- Article
- Signals from the deep: reach-related activity in the human superior colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Anxiety, a benefit and detriment to cognition: behavioral and magnetoencephalographic evidence from a mixed-saccade task.Brain and cognition · 2012Article
- Electrophysiological recordings in humans reveal reduced location-specific attentional-shift activity prior to recentering saccades.Journal of neurophysiology · 2012Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe superior colliculus (SC) has been shown to play a crucial role in the initiation and coordination of eye- and head-movements. The knowledge about the function of this structure is mainly based on single-unit recordings in animals with relatively few neuroimaging studies investigating eye-movement related brain activity in humans. METHODOLOGY/PRINCIPAL
findingsThe present study employed high-field (7 Tesla) functional magnetic resonance imaging (fMRI) to investigate SC responses during endogenously cued saccades in humans. In response to centrally presented instructional cues, subjects either performed saccades away from (centrifugal) or towards (centripetal) the center of straight gaze or maintained fixation at the center position. Compared to central fixation, the execution of saccades elicited hemodynamic activity within a network of cortical and subcortical areas that included the SC, lateral geniculate nucleus (LGN), occipital cortex, striatum, and the pulvinar. CONCLUSIONS/SIGNIFICANCE: Activity in the SC was enhanced contralateral to the direction of the saccade (i.e., greater activity in the right as compared to left SC during leftward saccades and vice versa) during both centrifugal and centripetal saccades, thereby demonstrating that the contralateral predominance for saccade execution that has been shown to exist in animals is also present in the human SC. In addition, centrifugal saccades elicited greater activity in the SC than did centripetal saccades, while also being accompanied by an enhanced deactivation within the prefrontal default-mode network. This pattern of brain activity might reflect the reduced processing effort required to move the eyes toward as compared to away from the center of straight gaze, a position that might serve as a spatial baseline in which the retinotopic and craniotopic reference frames are aligned.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.