ArticleJournal of neuropathology and experimental neurology2010
Pericontusion axon sprouting is spatially and temporally consistent with a growth-permissive environment after traumatic brain injury.
Article in Journal of neuropathology and experimental neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Sequential release ofMaterials today. Bio · 2026Article
- Regional and Global Changes in Brain Structure 1-Year Post Pediatric "Mild" Traumatic Brain Injury.Annals of neurology · 2025Article
- Article
- Differential Patterns of Change in Brain Connectivity Resulting from Severe Traumatic Brain Injury.Brain connectivity · 2022Article
- Acquired Brain Injury in Adults: A Review of Pathophysiology, Recovery, and Rehabilitation.Perspectives of the ASHA special interest groups · 2021Article
- Decreased Level of Exosomal miR-5121 Released from Microglia Suppresses Neurite Outgrowth and Synapse Recovery of Neurons Following Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?Frontiers in cellular neuroscience · 2021Review
- The innate immune toll-like-receptor-2 modulates the depressogenic and anorexiolytic neuroinflammatory response in obstructive sleep apnoea.Scientific reports · 2020Article
- Microglial process convergence on axonal segments in health and disease.Neuroimmunology and neuroinflammation · 2020Article
- Operation Brain Trauma Therapy: An Exploratory Study of Levetiracetam Treatment Following Mild Traumatic Brain Injury in the Micro Pig.Frontiers in neurology · 2020Article
- Perineuronal Nets and Their Role in Synaptic Homeostasis.International journal of molecular sciences · 2019Review
- Quantitative changes in perineuronal nets in development and posttraumatic condition.Journal of molecular histology · 2019Article
- Juvenile Traumatic Brain Injury Results in Cognitive Deficits Associated with Impaired Endoplasmic Reticulum Stress and Early Tauopathy.Developmental neuroscience · 2018Article
- The Perineuronal 'Safety' Net? Perineuronal Net Abnormalities in Neurological Disorders.Frontiers in molecular neuroscience · 2018Review
- Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics.Neural plasticity · 2018Review
- CSPGs inhibit axon branching by impairing mitochondria-dependent regulation of actin dynamics and axonal translation.Developmental neurobiology · 2017Article
- Hippocampal Perineuronal Nets Are Required for the Sustained Antidepressant Effect of Ketamine.The international journal of neuropsychopharmacology · 2017Article
- Understanding the Mechanisms of Recovery and/or Compensation following Injury.Neural plasticity · 2017Review
- Subacute Pain after Traumatic Brain Injury Is Associated with Lower Insular N-Acetylaspartate Concentrations.Journal of neurotrauma · 2016Article
- Bi-directional changes in fractional anisotropy after experiment TBI: Disorganization and reorganization?NeuroImage · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We previously reported that pericontusional extracellular chondroitin sulfate proteoglycans (CSPGs) are profoundly reduced for 3 weeks after experimental traumatic brain injury, indicating a potential growth-permissive window for plasticity. Here, we investigate the extracellular environment of sprouting neurons after controlled cortical impact injury in adult rats to determine the spatial and temporal arrangement of inhibitory and growth-promoting molecules in relation to growth-associated protein 43-positive (GAP43+) neurons. Spontaneous cortical sprouting was maximal in pericontused regions at 7 and 14 days after injury but absent by 28 days. Perineuronal nets containing CSPGs were reduced at 7 days after injury in the pericontused region (p < 0.05), which was commensurate with a reduction in extracellular CSPGs. Sprouting was restricted to the perineuronal nets and CSPG-deficient regions at 7 days, indicating that the pericontused region is temporarily and spatially permissive to new growth. At this time point,GAP43+ neurons were associated with brain regions containing cells positive for polysialic acid neural cell adhesion molecule but not with fibronectin-positive cells. Brain-derived neurotrophic factor was reduced in the immediate pericontused region at 7 days. Along with prior Western blot evidence, these data suggest that a lowered intrinsic growth stimulus, together with a later return of growth-inhibitory CSPGs, may contribute to the ultimate disappearance of sprouting neurons after traumatic brain injury.
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