ArticleJournal of neural engineering2010
Chronic network stimulation enhances evoked action potentials.
Article in Journal of neural engineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation.The European journal of neuroscience · 2024Article
- The Profile of Network Spontaneous Activity and Functional Organization Interplay in Hierarchically Connected Modular Neural Networks In Vitro.Micromachines · 2024Article
- Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells.Cells · 2021Article
- Plasticity and Adaptation in Neuromorphic Biohybrid Systems.iScience · 2020Review
- Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis.Scientific reports · 2020Article
- Pattern separation and completion of distinct axonal inputs transmitted via micro-tunnels between co-cultured hippocampal dentate, CA3, CA1 and entorhinal cortex networks.Journal of neural engineering · 2018Article
- Theta rhythm-like bidirectional cycling dynamics of living neuronal networks in vitro.PloS one · 2018Article
- Sparse and Specific Coding during Information Transmission between Co-cultured Dentate Gyrus and CA3 Hippocampal Networks.Frontiers in neural circuits · 2017Article
- Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays.Frontiers in neuroscience · 2016Article
- Barbed channels enhance unidirectional connectivity between neuronal networks cultured on multi electrode arrays.Frontiers in neuroscience · 2015Article
- Functional connectivity in in vitro neuronal assemblies.Frontiers in neural circuits · 2015Review
- Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.Frontiers in cellular neuroscience · 2015Article
- Understanding the temporal evolution of neuronal connectivity in cultured networks using statistical analysis.BMC neuroscience · 2014Article
- Adaptive enhancement of learning protocol in hippocampal cultured networks grown on multielectrode arrays.Frontiers in neural circuits · 2013Article
- Modeling the formation process of grouping stimuli sets through cortical columns and microcircuits to feature neurons.Computational intelligence and neuroscience · 2013Review
- Optogenetic stimulation effectively enhances intrinsically generated network synchrony.Frontiers in neural circuits · 2013Article
- Synaptic potentiation facilitates memory-like attractor dynamics in cultured in vitro hippocampal networks.PloS one · 2013Article
- Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies.Journal of neural engineering · 2012Article
- Hippocampal networks on reliable patterned substrates.Journal of neuroscience methods · 2012Article
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Authors and funding
5 authors.
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Abstract
Neurons cultured on multielectrode arrays almost always lack external stimulation except during the acute experimental phase. We have investigated the effects of chronic stimulation during the course of development in cultured hippocampal neural networks by applying paired pulses at half of the electrodes for 0, 1 or 3 r/day for 8 days. Spike latencies increased from 4 to 16 ms as the distance from the stimulus increased from 200 to 1700 microm, suggesting an average of four synapses over this distance. Compared to no chronic stimulation, our results indicate that chronic stimulation increased evoked spike counts per stimulus by 50% at recording sites near the stimulating electrode and increased the instantaneous firing rate. On trials where both pulses elicited responses, spike count was 40-80% higher than when only one of the pulses elicited a response. In attempts to identify spike amplitude plasticity, we found mainly amplitude variation with different latencies suggesting recordings from neurons with different identities. These data suggest plastic network changes induced by chronic stimulation that enhance the reliability of information transmission and the efficiency of multisynaptic network communication.
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