ArticleGenetics2010
Deleterious mutations and selection for sex in finite diploid populations.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Population-level consequences of inheritable somatic mutations and the evolution of mutation rates in plants.Proceedings. Biological sciences · 2021Article
- A simple expression for the strength of selection on recombination generated by interference among mutations.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Higher rates of sex evolve during adaptation to more complex environments.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Background Selection in Partially Selfing Populations.Genetics · 2016Article
- Article
- Does the avoidance of sexual costs increase fitness in asexual invaders?Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The evolution of obligate sex: the roles of sexual selection and recombination.Ecology and evolution · 2015Article
- Article
- Relative effects of segregation and recombination on the evolution of sex in finite diploid populations.Heredity · 2013Article
- The evolution of sex is favoured during adaptation to new environments.PLoS biology · 2012Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In diploid populations, indirect benefits of sex may stem from segregation and recombination. Although it has been recognized that finite population size is an important component of selection for recombination, its effects on selection for segregation have been somewhat less studied. In this article, we develop analytical two- and three-locus models to study the effect of recurrent deleterious mutations on a modifier gene increasing sex, in a finite diploid population. The model also incorporates effects of mitotic recombination, causing loss of heterozygosity (LOH). Predictions are tested using multilocus simulations representing deleterious mutations occurring at a large number of loci. The model and simulations show that excess of heterozygosity generated by finite population size is an important component of selection for sex, favoring segregation when deleterious alleles are nearly additive to dominant. Furthermore, sex tends to break correlations in homozygosity among selected loci, which disfavors sex when deleterious alleles are either recessive or dominant. As a result, we find that it is difficult to maintain costly sex when deleterious alleles are recessive. LOH tends to favor sex when deleterious mutations are recessive, but the effect is relatively weak for rates of LOH corresponding to current estimates (of the order 10(-4)-10(-5)).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.