ArticleGenetics2010
Regulation of bacterial conjugation in microaerobiosis by host-encoded functions ArcAB and sdhABCD.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- ArcA modulates multidrug resistance and compound susceptibility inMicrobiology spectrum · 2025Article
- A synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance.Nature communications · 2024Article
- The Effect of Outer Space and Other Environmental Cues on Bacterial Conjugation.Microbiology spectrum · 2023Article
- Conjugation's Toolkit: the Roles of Nonstructural Proteins in Bacterial Sex.Journal of bacteriology · 2023Review
- The ArcAB Two-Component System: Function in Metabolism, Redox Control, and Infection.Microbiology and molecular biology reviews : MMBR · 2022Review
- Scanning mutagenesis of RNA-binding protein ProQ reveals a quality control role for the Lon protease.RNA (New York, N.Y.) · 2021Article
- Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug-Resistance Plasmids.Molecular biology and evolution · 2021Article
- Transfer of Antibiotic Resistance Plasmid from CommensalLife (Basel, Switzerland) · 2021Article
- Functional expansion of a TCA cycle operon mRNA by a 3' end-derived small RNA.Nucleic acids research · 2019Article
- Cooperative Function of TraJ and ArcA in Regulating the F PlasmidJournal of bacteriology · 2019Article
- Evolution of Salmonella within Hosts.Trends in microbiology · 2018Review
- Spread and Persistence of Virulence and Antibiotic Resistance Genes: A Ride on the F Plasmid Conjugation Module.EcoSal Plus · 2018Review
- Natural and Artificial Strategies To Control the Conjugative Transmission of Plasmids.Microbiology spectrum · 2018Review
- Signal transduction pathway mediated by the novel regulator LoiA for low oxygen tension induced Salmonella Typhimurium invasion.PLoS pathogens · 2017Article
- Article
- Bacterial Stress Responses during Host Infection.Cell host & microbe · 2016Review
- Small RNA-based feedforward loop with AND-gate logic regulates extrachromosomal DNA transfer in Salmonella.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Assessment of conjugal transfer of antibiotic resistance genes in Salmonella Typhimurium exposed to bile salts.Journal of microbiology (Seoul, Korea) · 2014Article
- Transcriptional regulation of bacterial virulence gene expression by molecular oxygen and nitric oxide.Virulence · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The virulence plasmid of Salmonella enterica (pSLT) is an F-like conjugative plasmid. High rates of pSLT transfer occur in the mammalian gut, a microaerobic environment. In this study, we describe genetic screens for host-encoded activators and repressors of the transfer operon (tra) of pSLT. We show that the transcription factor ArcA is an activator of conjugation, especially under microaerobiosis. In turn, succinate dehydrogenase (SdhABCD) is a repressor of mating in aerobiosis. ArcA binds upstream of the main tra promoter (p(traY)) and activates tra transcription, as previously described in F, R1, and R100. In the absence of ArcA, transfer of pSLT decreased 7-fold in aerobiosis and >100-fold in microaerobiosis. In aerobiosis, ArcA activates the traY promoter in an ArcB-independent manner, as described in other F-like plasmids. In microaerobiosis, however, the ArcB sensor is necessary for activation of p(traY). Lack of Sdh causes a >20-fold increase in pSLT transfer in aerobiosis, but has little effect under microaerobiosis. Sdh inhibits conjugal transfer by reducing traJ transcription, probably in an indirect manner. In turn, the sdhCDAB operon is repressed by the ArcAB system under microaerobiosis. Hence, the ArcAB two-component system of S. enterica stimulates pSLT transfer under microaerobiosis by two concerted actions: activation of the tra operon and repression of the sdhCDAB operon.
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Registered trials
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