ArticleTechnology in cancer research & treatment2010
Combined fluorescence and X-Ray tomography for quantitative in vivo detection of fluorophore.
Article in Technology in cancer research & treatment, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Antibody-functionalized gold nanospheres for multimodal imaging.Scientific reports · 2026Article
- A Novel Mouse Segmentation Method Based on Dynamic Contrast Enhanced Micro-CT Images.PloS one · 2017Article
- Multimodal fluorescence-mediated tomography and SPECT/CT for small-animal imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Article
- DOT corrected fluorescence molecular tomography using targeted contrast agents for small animal tumor imaging.Journal of X-ray science and technology · 2013Article
- A compact frequency-domain photon migration system for integration into commercial hybrid small animal imaging scanners for fluorescence tomography.Physics in medicine and biology · 2012Article
- FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography.Nature methods · 2012Article
- Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging.Biomedical optics express · 2011Article
- Fluorescence molecular tomography: principles and potential for pharmaceutical research.Pharmaceutics · 2011Article
- Quantitative fluorescence tomography using a trimodality system: in vivo validation.Journal of biomedical opticsArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Initial results from a novel dual modality preclinical imager which combines non-contact fluorescence tomography (FT) and x-ray computed tomography (CT) for preclinical functional and anatomical in vivo imaging are presented. The anatomical data from CT provides a priori information to the FT reconstruction to create overlaid functional and anatomical images with accurate localization and quantification of fluorophore distribution. Phantoms with inclusions containing Indocyanine-Green (ICG), and with heterogeneous backgrounds including iodine in compartments at different concentrations for CT contrast, have been imaged with the dual modality FT/CT system. Anatomical information from attenuation maps and optical morphological information from absorption and scattering maps are used as a priori information in the FT reconstruction. Although ICG inclusions can be located without the a priori information, the recovered ICG concentration shows 75% error. When the a priori information is utilized, the ICG concentration can be recovered with only 15% error. Developing the ability to accurately quantify fluorophore concentration in anatomical regions of interest may provide a powerful tool for in vivo small animal imaging.
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Registered trials
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