ArticleWorld journal of gastroenterology2010
Expression of p53, c-erbB-2 and Ki67 in intestinal metaplasia and gastric carcinoma.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Network pharmacology- and molecular docking-based exploration of the molecular mechanism underlying Jianpi Yiwei Recipe treatment of gastric cancer.World journal of gastrointestinal oncology · 2024Article
- Systematic Review and Meta-analysis of TP53, HER2/ERBB2, KRAS, APC, and PIK3CA Genes Expression Pattern in Gastric Cancer.Middle East journal of digestive diseases · 2022Review
- Effects of HFrontiers in oncology · 2022Article
- Eradication ofFrontiers in microbiology · 2021Review
- Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer.World journal of surgical oncology · 2020Article
- Gastric Damage and Cancer-Associated Biomarkers inFrontiers in microbiology · 2020Review
- Development of Triptolide Self-Microemulsifying Drug Delivery System and Its Anti-tumor Effect on Gastric Cancer Xenografts.Frontiers in oncology · 2019Article
- Article
- Incorporation of p-53 mutation status and Ki-67 proliferating index in classifying Her2-neu positive gastric adenocarcinoma.The Libyan journal of medicine · 2018Article
- Association of HER2 gene amplification and tumor progression in early gastric cancer.Virchows Archiv : an international journal of pathology · 2018Article
- Clinical significance of TM4SF1 as a tumor suppressor gene in gastric cancer.Cancer medicine · 2018Article
- The Expression of MCM7 is a Useful Biomarker in the Early Diagnostic of Gastric Cancer.Pathology oncology research : POR · 2018Article
- Identification of AQP3 and CD24 as biomarkers for carcinogenesis of gastric intestinal metaplasia.Oncotarget · 2017Article
- Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis.United European gastroenterology journal · 2017Article
- Increased Proliferative Activity Accompanies the Local Inflammatory Response of Gastric Mucosa After Intragastric Balloon Insertion.Digestive diseases and sciences · 2016Article
- p53, a potential predictor of Helicobacter pylori infection-associated gastric carcinogenesis?Oncotarget · 2016Review
- Predictable factors for lymph node metastasis in early gastric cancer analysis of clinicopathologic factors and biological markers.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Detecting of gastric cancer by Bcl-2 and Ki67.International journal of clinical and experimental pathology · 2015Article
- Endoscopic resection as a first therapy for gastric epithelial atypia: is it reasonable?Digestive diseases and sciences · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare two types of classification of intestinal metaplasia (IM) of the stomach and to explore their relationship to gastric carcinoma.
methodsForty-seven cases of gastric IM were classified into type I, type II or type III according to mucin histochemical staining and compared with a novel classification in which the specimens were classified into simple IM (SIM) or atypical IM according to polymorphism in terms of atypical changes of the metaplastic epithelium. Forty-seven IM and thirty-seven gastric carcinoma samples were stained for p53, c-erbB-2 and Ki67 proteins by Envision immunohistochemical technique.
resultsThere were no significant differences in the expression of p53 and c-erbB-2 among type I, type II, type III IM and gastric carcinomas. The positive expression rate of Ki67 was significantly higher in gastric carcinomas than in type I IM while no significant Ki67 expression differences were observed among type II, type III IM and gastric carcinomas. The expression of p53, c-erbB-2 and Ki67 proteins in 20 SIM, 27 Atypical IM and 37 gastric carcinomas showed significant differences between SIM and gastric carcinomas while no significant differences were observed between Atypical IM and gastric carcinomas.
conclusionAtypical IM may better reveal the precancerous nature of IM and could be a helpful indicator in the clinical follow up of patients.
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