ArticleHuman brain mapping2010
The neural control of bimanual movements in the elderly: Brain regions exhibiting age-related increases in activity, frequency-induced neural modulation, and task-specific compensatory recruitment.
Article in Human brain mapping, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed.
- Trial
- The effects of handedness and age on hand role selection in bimanual tasks.Experimental brain research · 2026Article
- Article
- Aging impairs bimanual isometric force smoothness.EXCLI journal · 2026Article
- The ageing brain: Cortical overactivation - How does it evolve?The Journal of physiology · 2026Review
- Exploring brain activation during a buttoning task in adults: A functional near infrared spectroscopy investigation.Neuroimage. Reports · 2025Article
- Concurrent listening impairs compensatory postural control mechanisms in middle and late adulthood.PloS one · 2025Article
- GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups.Frontiers in aging neuroscience · 2025Article
- Assessing age-related changes in brain activity during isometric upper and lower limb force control tasks.Brain structure & function · 2024Article
- Multitasking across the lifespan in different task contexts.Scientific reports · 2024Article
- High-intensity acute exercise impacts motor learning in healthy older adults.NPJ science of learning · 2024Article
- Aging, Neurodegenerative Disorders, and Cerebellum.International journal of molecular sciences · 2024Review
- Assessing neuromuscular system via patellar tendon reflex analysis using EMG in healthy individuals.Frontiers in neurology · 2024Article
- Exploring Asymmetric Fine Motor Impairment Trends in Early Parkinson's Disease via Keystroke Typing.Movement disorders clinical practice · 2023Article
- Brain functional characterization of response-code conflict in dual-tasking and its modulation by age.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Interactions between the aging brain and motor task complexity across the lifespan: balancing brain activity resource demand and supply.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Test-retest reliability of a finger-tapping fMRI task in a healthy population.The European journal of neuroscience · 2023Article
- Cytoarchitectonic mapping of the human frontal operculum-New correlates for a variety of brain functions.Frontiers in human neuroscience · 2023Article
- Compounding Vulnerability in the Neurocircuitry of Addiction: Longitudinal Functional Connectivity Changes in Alcohol Use Disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Article
- Aging and Complexity Effects on Hemisphere-Dependent Movement-Related Beta Desynchronization during Bimanual Motor Planning and Execution.Brain sciences · 2022Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Coordinated hand use is an essential component of many activities of daily living. Although previous studies have demonstrated age-related behavioral deficits in bimanual tasks, studies that assessed the neural basis underlying such declines in function do not exist. In this fMRI study, 16 old and 16 young healthy adults performed bimanual movements varying in coordination complexity (i.e., in-phase, antiphase) and movement frequency (i.e., 45, 60, 75, 90% of critical antiphase speed) demands. Difficulty was normalized on an individual subject basis leading to group performances (measured by phase accuracy/stability) that were matched for young and old subjects. Despite lower overall movement frequency, the old group "overactivated" brain areas compared with the young adults. These regions included the supplementary motor area, higher order feedback processing areas, and regions typically ascribed to cognitive functions (e.g., inferior parietal cortex/dorsolateral prefrontal cortex). Further, age-related increases in activity in the supplementary motor area and left secondary somatosensory cortex showed positive correlations with coordinative ability in the more complex antiphase task, suggesting a compensation mechanism. Lastly, for both old and young subjects, similar modulation of neural activity was seen with increased movement frequency. Overall, these findings demonstrate for the first time that bimanual movements require greater neural resources for old adults in order to match the level of performance seen in younger subjects. Nevertheless, this increase in neural activity does not preclude frequency-induced neural modulations as a function of increased task demand in the elderly.
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