ArticleEuropean journal of applied physiology2010
Caffeine improves supramaximal cycling but not the rate of anaerobic energy release.
Article in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Anaerobic and Aerobic Energy System Contribution During Maximal Exercise: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- The effects of exercise training and nutritional supplementation on taekwondo performance: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Pooled it
- Effects of caffeine ingestion on physiological indexes of human neuromuscular fatigue: A systematic review and meta-analysis.Brain and behavior · 2022Pooled it
- Acute caffeine supplementation in combat sports: a systematic review.Journal of the International Society of Sports Nutrition · 2018Pooled it
- Effects of Dietary Nitrate and Caffeine on End Power and Work Above End Power During a 3 min All-Out Test in Trained Male Cyclists.Nutrients · 2026Trial
- The dose-dependent effect of caffeine supplementation on performance, reaction time and postural stability in CrossFit - a randomized placebo-controlled crossover trial.Journal of the International Society of Sports Nutrition · 2024Trial
- Acute caffeine intake increases muscle oxygen saturation during a maximal incremental exercise test.British journal of clinical pharmacology · 2020Trial
- Caffeine and sodium bicarbonate supplementation alone or together improve karate performance.Journal of the International Society of Sports Nutrition · 2019Trial
- Dose-dependent effect of caffeine supplementation on judo-specific performance and training activity: a randomized placebo-controlled crossover trial.Journal of the International Society of Sports Nutrition · 2019Trial
- Caffeine Supplementation Improves Anaerobic Performance and Neuromuscular Efficiency and Fatigue in Olympic-Level Boxers.Nutrients · 2019Trial
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- THE EFFECT OF CAFFEINE SUPPLEMENTATION ON TRAINED INDIVIDUALS SUBJECTED TO MAXIMAL TREADMILL TEST.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Trial
- Effects of caffeine ingestion on endurance performance in mentally fatigued individuals.European journal of applied physiology · 2016Trial
- Caffeine ingestion improves power output decrement during 3-min all-out exercise.European journal of applied physiology · 2016Trial
- The Effects of Caffeine Supplementation on Physiological Responses to Submaximal Exercise in Endurance-Trained Men.PloS one · 2016Trial
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- Caffeine alters anaerobic distribution and pacing during a 4000-m cycling time trial.PloS one · 2013Trial
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to determine if improved supramaximal exercise performance in trained cyclists following caffeine ingestion was associated with enhanced O(2) uptake (VO2 kinetics), increased anaerobic energy provision (accumulated O(2)-AO(2)-deficit), or a reduction in the accumulation of metabolites (for example, K(+)) associated with muscular fatigue. Six highly trained male cyclists (VO2peak 68 +/- 8 mL kg(-1) min(-1)) performed supramaximal (120% VO2peak) exercise bouts to exhaustion on an electronically braked cycle ergometer, following double-blind and randomized ingestion of caffeine/placebo (5 mg kg(-1)). Time to exhaustion (TE), VO2 kinetics, AO(2) deficit, blood lactate (La(-)), plasma potassium (K(+)), caffeine and paraxanthine concentrations were measured. Caffeine ingestion elicited significant increases in TE (14.8%, p < 0.01) and AO(2) deficit (6.5%, p < 0.05). In contrast, no changes were observed in AO(2) deficit at isotime, VO2 kinetics, blood [La(-)] at exhaustion or peak [K(+)] following caffeine ingestion. However, [K(+)] was significantly reduced (13.4%, p < 0.01) during warm-up cycling immediately prior to the onset of the supramaximal bout for the caffeine trials, compared with placebo. It appears that caffeine ingestion is beneficial to supramaximal cycling performance in highly trained men. The reduced plasma [K(+)] during submaximal warm-up cycling may prolong the time taken to reach critical [K(+)] at exhaustion, thus delaying fatigue. Considering caffeine ingestion did not change VO2 kinetics or isotime AO(2) deficit, increases in absolute AO(2) deficit may be a consequence of prolonged TE, rather than causal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.