ArticleChromosoma2010
E(y)2/Sus1 is required for blocking PRE silencing by the Wari insulator in Drosophila melanogaster.
Article in Chromosoma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Multiple Roles of dXNP and dADD1-International journal of molecular sciences · 2023Review
- Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila.Genetics · 2023Article
- No apparent role for the Wari insulator in transcriptional regulation of the endogenousmicroPublication biology · 2023Article
- Boundaries potentiate polycomb response element-mediated silencing.BMC biology · 2021Article
- The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.PloS one · 2018Article
- EAST affects the activity of Su(Hw) insulators by two different mechanisms in Drosophila melanogaster.Chromosoma · 2017Article
- Functional Requirements for Fab-7 Boundary Activity in the Bithorax Complex.Molecular and cellular biology · 2015Article
- EAST Organizes Drosophila Insulator Proteins in the Interchromosomal Nuclear Compartment and Modulates CP190 Binding to Chromatin.PloS one · 2015Article
- The Drosophila eve insulator Homie promotes eve expression and protects the adjacent gene from repression by polycomb spreading.PLoS genetics · 2013Article
- Article
- Functional sub-division of the Drosophila genome via chromatin looping: the emerging importance of CP190.Nucleus (Austin, Tex.)Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Chromatin insulators affect interactions between promoters and enhancers/silencers and function as barriers to the spread of repressive chromatin. Recently, we have found an insulator, named Wari, located on the 3' side of the white gene. Here, we show that the previously identified 368-bp core of this insulator is sufficient for blocking Polycomb response element-mediated silencing. Although Wari does not contain binding sites for known insulator proteins, the E(y)2 and CP190 proteins bind to Wari as well as to the Su(Hw)-containing insulators in vivo. It may well be that these proteins are recruited to the insulator by as yet unidentified DNA-binding protein. Partial inactivation of E(y)2 in a weak e(y)2 ( u1 ) mutation impairs only the anti-silencing but not the enhancer-blocking activity of the Wari insulator. Thus, the E(y)2 protein in different Drosophila insulators serves to protect gene expression from silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.