Evidence map›Paper›PMID 20082055›Full record

Trial reportThe journal of nutrition, health & aging2010

Identifying and preventing adverse drug events in elderly hospitalised patients: a randomised trial of a program to reduce adverse drug effects.

C Trivalle, T Cartier, C Verny, A-M Mathieu, P Davrinche, H Agostini, L Becquemont, P Demolis, IMEPAG GROUP

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of nutrition, health & aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 7 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 7 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Review
  10. The impact of clinical pharmacist implemented education on the incidence of prescribing errors in COVID-19 patients.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Article
  11. Article
  12. Review
  13. Review
  14. Patient harm from cardiovascular medications.Therapeutic advances in drug safety · 2021
    Review
  15. Article
  16. Article
  17. Preventable adverse drug events: Descriptive epidemiology.British journal of clinical pharmacology · 2020
    Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

C TrivallePole Vieillissement, Readaptation et Accompagnement, Hopital Paul Brousse, (APHP), Villejuif, France. christophe.trivalle@pbr.aphp.fr
T Cartier
C Verny
A-M Mathieu
P Davrinche
H Agostini
L Becquemont
P Demolis
IMEPAG GROUP
Bicêtre Hospital · FRHôpital Corentin-Celton · FRHôpital Paul-Brousse · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEvaluate the impact of educational intervention in decreasing ADEs in elderly patients in a hospital setting.

designRandomised prospective study.

settingThe study was performed in France in the Paris area, in 16 rehabilitation geriatric centres of APHP (Assistance Publique - Hôpitaux de Paris). Patient capacity per centre varied from 15 to 57 with a total of 526.

participantsAll the patients > or = 65 years hospitalized during the 4 week study period were included. MEASUREMENTS: During a first 2 week phase without intervention ADE's were recorded in all centres. Then units were then randomised for an educational intervention or not. The educational phase lasted 1 week, without ADE tracking. Then, both types of units (I+ and I-) recorded ADEs for 2 weeks. Possible drug-related incidents were detected using a standardized check list (nurses) and a weekly review of all charts by investigators. Possible drug-related incidents were analysed by a group of reviewers selected from the authors to classify them as ADE or not.

results576 patients (mean age: 83.6 +/- 7.9 years) were consecutively included. The mean number of drugs at inclusion was 9.4 +/- 4.24 drugs per patient. 223 out of 755 events were considered "probable" ADEs (29.5%). Among the 223 ADEs, 62 (28%) could have been prevented. The main outcome of this trial was the change in the proportion of ADEs in elderly patients in the intervention-units, compared to the control group. The main errors were: to high a dose (26%), double therapy (21%), under dose (13%), inappropriate drug (13%), drug-drug interaction (6%), previous same adverse drug reaction (3%) and miscellaneous (11.18%). After a specific educational intervention program, there were fewer ADEs in the intervention group (n = 38, 22%) than in the control group (n = 63, 36%; p = 0.004).

conclusionEducational programs could help reduce the prevalence of ADEs by 14% and encourage physicians to change outdated prescription habits.

Indexed as

Drug-Related Side Effects and Adverse ReactionsPatient Education as TopicAdverse Drug Reaction Reporting SystemsAged, 80 and overDose-Response Relationship, DrugDrug HypersensitivityDrug InteractionsDrug MonitoringDrug OverdoseFemaleHealth EducationHumansInpatientsMaleProspective Studies

Identifiers

PMID20082055
PMCPMC12880344
OpenAlexW1988923606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.