ArticleCellular & molecular immunology2010
TGF-beta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells.
Article in Cellular & molecular immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Apheresis platelets modulate myeloid dendritic cell immune responses.Scientific reports · 2025Article
- The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease.International journal of molecular sciences · 2022Review
- Exosomes with FOXP3 from gene-modified dendritic cells ameliorate the development of EAE by regulating the balance of Th/Treg.International journal of medical sciences · 2022Article
- MicroRNA-138-5p Suppresses Non-small Cell Lung Cancer Cells by Targeting PD-L1/PD-1 to Regulate Tumor Microenvironment.Frontiers in cell and developmental biology · 2020Article
- Exosomes: Versatile Nano Mediators of Immune Regulation.Cancers · 2019Review
- Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells.Cellular & molecular immunology · 2019Article
- CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production.Cell death & disease · 2018Article
- Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-β.Immunology and cell biology · 2016Article
- Generation of regulatory dendritic cells after treatment with paeoniflorin.Immunologic research · 2016Article
- The Effect of Traditional Chinese Formula Danchaiheji on the Differentiation of Regulatory Dendritic Cells.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Synergy of Transforming Growth Factor Beta 1 and All Trans Retinoic Acid in the Treatment of Inflammatory Bowel Disease: Role of Regulatory T cells.Journal of gastroenterology, pancreatology & liver disorders · 2016Article
- Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Review
- Serum adipokines in inflammatory bowel disease.World journal of gastroenterology · 2014Article
- Effect of bone marrow-derived CD11b(+)F4/80 (+) immature dendritic cells on the balance between pro-inflammatory and anti-inflammatory cytokines in DBA/1 mice with collagen-induced arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Characterization of Bone Marrow-Derived Dendritic Cells Developed in Serum-Free Media and their Ability to Prevent Type 1 Diabetes in Nonobese Diabetic Mice.Journal of blood disorders & transfusion · 2014Article
- Oral Administration of Interleukin-10 and Anti-IL-1 Antibody Ameliorates Experimental Intestinal Inflammation.Gastroenterology research · 2013Article
- Functional study of immature dendritic cells co-transfected with IL-10 and TGF-beta 1 genes in vitro.Molecular biology reports · 2012Article
- Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease.World journal of gastroenterology · 2011Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) is caused by an uncontrolled immune response in the intestinal lumen, leading to inflammation in genetically predisposed individuals. Immunotherapy may be a promising approach to the treatment of IBD. Here, we show that transforming growth factor-beta1 (TGF-beta1) gene-modified immature dendritic cells (imDCs) could enhance the inhibitory function of imDCs and delay the progress of IBD induced by dextran sodium sulfate in mice. The results of fluorescence-activated cell sorter (FACS) demonstrated that this protective effect is mediated partially by inducing CD4(+)Foxp3(+) regulatory T cells (Tregs) in mesentery lymph nodes to control inflammation. In vitro experiments also supported this hypothesis. In conclusion, we provide evidence that TGF-beta1-modified bone marrow-derived imDCs may have a therapeutic effect to IBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.