ReviewNature chemical biology2010
AMPA receptors and synaptic plasticity: a chemist's perspective.
Review in Nature chemical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Effect of Damaging Rare Mutations in Synapse-Related Gene Sets on Response to Short-term Antipsychotic Medication in Chinese Patients With Schizophrenia: A Randomized Clinical Trial.JAMA psychiatry · 2018Trial
- Clinical application of repetitive transcranial magnetic stimulation for post-traumatic stress disorder: A literature review.World journal of clinical cases · 2021Review
- Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking.Nature communications · 2021Article
- UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function.Molecular psychiatry · 2020Article
- The Synaptic Theory of Memory: A Historical Survey and Reconciliation of Recent Opposition.Frontiers in systems neuroscience · 2018Article
- Chemical labelling for visualizing native AMPA receptors in live neurons.Nature communications · 2017Article
- Mechanism of Action for rTMS: A Working Hypothesis Based on Animal Studies.Frontiers in physiology · 2017Review
- Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells.Nature chemistry · 2016Article
- AMPA receptors as a molecular target in epilepsy therapy.Acta neurologica Scandinavica. Supplementum · 2013Review
- AMPA receptor mediated behavioral plasticity in the isolated rat spinal cord.Behavioural brain research · 2013Article
- The cell biology of synaptic plasticity.Science (New York, N.Y.) · 2011Article
- Structural landscape of isolated agonist-binding domains from single AMPA receptors.Nature chemical biology · 2011Article
- Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn.The European journal of neuroscience · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of the mammalian brain to undergo experience-based adaptations is among its most important and fascinating properties. Such plasticity is reflected in the capacity of neuronal activity to continuously modify the neural circuitry that underlies thought, feeling and behavior. The locus of this plasticity occurs at the level of synapses, the specialized junctions where one neuron receives chemical signals from another. Synaptic connections become stronger or weaker in response to specific patterns of activity. This activity drives regulated changes in the neurotransmitter released by presynaptic neurons and in the receptors localized on postsynaptic neurons. Detailed studies of these receptors have advanced our understanding of synaptic plasticity. However, many key questions remain unresolved, and over the past decade innovative chemical approaches have emerged to tackle them. Here we review these chemical tools and their application to unraveling the molecular basis of synaptic plasticity.
Indexed as
Identifiers
20081822What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.