ArticleNucleic acids research2010
Anatomy of mouse recombination hot spots.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks.Cell research · 2020Article
- HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots.Genes & development · 2020Article
- The impact of poly-A microsatellite heterologies in meiotic recombination.Life science alliance · 2019Article
- Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice.Cell cycle (Georgetown, Tex.) · 2017Article
- Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.Molecular and cellular biology · 2017Article
- Article
- A Glance at Recombination Hotspots in the Domestic Cat.PloS one · 2016Article
- Local and sex-specific biases in crossover vs. noncrossover outcomes at meiotic recombination hot spots in mice.Genes & development · 2015Article
- R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias.PloS one · 2014Article
- Contrasted patterns of crossover and non-crossover at Arabidopsis thaliana meiotic recombination hotspots.PLoS genetics · 2013Article
- A comparative study of the recombination pattern in three species of Platyrrhini monkeys (primates).Chromosoma · 2011Article
- Genetic evidence that synaptonemal complex axial elements govern recombination pathway choice in mice.Genetics · 2011Article
- Article
- Initiation of meiotic recombination in mammals.Genes · 2010Article
- Comprehensive, fine-scale dissection of homologous recombination outcomes at a hot spot in mouse meiosis.Molecular cell · 2010Article
- Nucleosome occupancy landscape and dynamics at mouse recombination hotspots.EMBO reports · 2010Article
- Organization and roles of nucleosomes at mouse meiotic recombination hotspots.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Genome-wide analyses have suggested thousands of meiotic recombination hot spots across mammalian genomes. However, very few hot spots have been directly analyzed at a sub-kb scale for crossover (CO) activity. Using recombinant inbred strains as a CO library, here we report the identification and detailed characterization of seven new meiotic hot spots on mouse chromosome 19, more than doubling the number of currently available mouse hot spots. Although a shared feature is the narrow 1.5-2.5-kb width of these recombinogenic sites, these analyses revealed that hot spots have diverse sequence attributes and distinct symmetric and asymmetric CO profiles. Interestingly, CO molecules with discontinuous conversion tracts are commonly observed, contrasting with those found in human. Furthermore, unlike human hot spots, those present in the mouse do not necessarily have a quasi-normal CO distribution but harbor CO repulsion zones within recombinogenic cores. We propose a model where local chromatin landscape directs these repulsion zones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.