ArticleThe Plant cell2010
Jasmonate and ppHsystemin regulate key Malonylation steps in the biosynthesis of 17-Hydroxygeranyllinalool Diterpene Glycosides, an abundant and effective direct defense against herbivores in Nicotiana attenuata.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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90 citing papers in PubMed, 178 citations in OpenAlex.
- Review
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- The Capsicum terpenoid biosynthetic module is affected by spider-mite herbivory.Plant molecular biology · 2023Article
- A persistent major mutation in canonical jasmonate signaling is embedded in an herbivory-elicited gene network.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Molecular and genetic insights into secondary metabolic regulation underlying insect-pest resistance in legumes.Functional & integrative genomics · 2023Review
- Harmonizing biosynthesis with post-ingestive modifications to understand the ecological functions of plant natural products.Natural product reports · 2022Review
- The downside of metabolic diversity: Postingestive rearrangements by specialized insects.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Phytocompounds as an Alternative Antimicrobial Approach in Aquaculture.Antibiotics (Basel, Switzerland) · 2022Review
- Specific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata.The Plant cell · 2021Article
- Fine mapping of a thrips resistance QTL in Capsicum and the role of diterpene glycosides in the underlying mechanism.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Processing of Airborne Green Leaf Volatiles for Their Glycosylation in the Exposed Plants.Frontiers in plant science · 2021Article
- Strigolactone signaling regulates specialized metabolism in tobacco stems and interactions with stem-feeding herbivores.PLoS biology · 2020Article
- Information theory tests critical predictions of plant defense theory for specialized metabolism.Science advances · 2020Article
- Transcriptome Profiling ofPlants (Basel, Switzerland) · 2020Article
- Silencing JA hydroxylases inPlant diversity · 2020Article
- NSs, the Silencing Suppressor of Tomato Spotted Wilt Orthotospovirus, Interferes With JA-Regulated Host Terpenoids Expression to AttractFrontiers in microbiology · 2020Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We identified 11 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) that occur in concentrations equivalent to starch (mg/g fresh mass) in aboveground tissues of coyote tobacco (Nicotiana attenuata) and differ in their sugar moieties and malonyl sugar esters (0-2). Concentrations of HGL-DTGs, particularly malonylated compounds, are highest in young and reproductive tissues. Within a tissue, herbivore elicitation changes concentrations and biosynthetic kinetics of individual compounds. Using stably transformed N. attenuata plants silenced in jasmonate production and perception, or production of N. attenuata Hyp-rich glycopeptide systemin precursor by RNA interference, we identified malonylation as the key biosynthetic step regulated by herbivory and jasmonate signaling. We stably silenced N. attenuata geranylgeranyl diphosphate synthase (ggpps) to reduce precursors for the HGL-DTG skeleton, resulting in reduced total HGL-DTGs and greater vulnerability to native herbivores in the field. Larvae of the specialist tobacco hornworm (Manduca sexta) grew up to 10 times as large on ggpps silenced plants, and silenced plants suffered significantly more damage from herbivores in N. attenuata's native habitat than did wild-type plants. We propose that high concentrations of HGL-DTGs effectively defend valuable tissues against herbivores and that malonylation may play an important role in regulating the distribution and storage of HGL-DTGs in plants.
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