ArticleGenes & development2010
A novel, noncanonical mechanism of cytoplasmic polyadenylation operates in Drosophila embryogenesis.
Article in Genes & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Maternal redd1 mRNA decline triggers mTORC1 activation during the blastula-gastrula transition in zebrafish embryos.The FEBS journal · 2026Article
- The molecular mechanisms underpinning maternal mRNA dormancy.Biochemical Society transactions · 2024Review
- Article
- Ataxin-2, Twenty-four, and Dicer-2 are components of a noncanonical cytoplasmic polyadenylation complex.Life science alliance · 2022Article
- Orb-dependent polyadenylation contributes to PLP expression and centrosome scaffold assembly.Development (Cambridge, England) · 2022Article
- Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation.RNA (New York, N.Y.) · 2018Article
- Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs.Nature structural & molecular biology · 2017Article
- mTAIL-seq reveals dynamic poly(A) tail regulation in oocyte-to-embryo development.Genes & development · 2016Article
- The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning.International journal of molecular sciences · 2015Article
- Cytoplasmic polyadenylation is a major mRNA regulator during oogenesis and egg activation in Drosophila.Developmental biology · 2013Article
- Circadian control of mRNA polyadenylation dynamics regulates rhythmic protein expression.Genes & development · 2012Article
- mRNA localization and translational control in Drosophila oogenesis.Cold Spring Harbor perspectives in biology · 2012Review
- Translational control by changes in poly(A) tail length: recycling mRNAs.Nature structural & molecular biology · 2012Review
- The poly(rC)-binding protein alphaCP2 is a noncanonical factor in X. laevis cytoplasmic polyadenylation.RNA (New York, N.Y.) · 2011Article
- Dynamic isomiR regulation in Drosophila development.RNA (New York, N.Y.) · 2010Article
- Specificity factors in cytoplasmic polyadenylation.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
5 authors.
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Abstract
Cytoplasmic polyadenylation is a widespread mechanism to regulate mRNA translation that requires two sequences in the 3' untranslated region (UTR) of vertebrate substrates: the polyadenylation hexanucleotide, and the cytoplasmic polyadenylation element (CPE). Using a cell-free Drosophila system, we show that these signals are not relevant for Toll polyadenylation but, instead, a "polyadenylation region" (PR) is necessary. Competition experiments indicate that PR-mediated polyadenylation is required for viability and is mechanistically distinct from the CPE/hexanucleotide-mediated process. These data indicate that Toll mRNA is polyadenylated by a noncanonical mechanism, and suggest that a novel machinery functions for cytoplasmic polyadenylation during Drosophila embryogenesis.
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