ArticleProceedings of the National Academy of Sciences of the United States of America2010
Genome-wide patterns of population structure and admixture in West Africans and African Americans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 278 papers, 3 of them syntheses that pooled it.
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Who cites it
278 citing papers in PubMed, 3 syntheses or guidelines pooled it, 475 citations in OpenAlex.
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- Recruitment of Yoruba families from Nigeria for genetic research: experience from a multisite keloid study.BMC medical ethics · 2014Pooled it
- Genome-wide association study of age at menarche in African-American women.Human molecular genetics · 2013Pooled it
- Presence of recombination hotspots throughout SLC6A3.PloS one · 2019Trial
- Whole-exome sequencing to analyze population structure, parental inbreeding, and familial linkage.Proceedings of the National Academy of Sciences of the United States of America · 2016Trial
- Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics.Journal of hypertension · 2013Trial
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- Influence of Ancestral and Geographic Factors on Intracerebral Hemorrhage Risks Among Africans and Americans.Stroke · 2025Article
- The Indian Ocean slave trade and colonial expansion resulted in strong sex-biased admixture in South Africa.American journal of human genetics · 2025Article
- Differential results of genetic risk scoring for multiple sclerosis in European and African American populations.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Subcontinental genetic variation in the All of Us Research Program: Implications for biomedical research.American journal of human genetics · 2025Article
- Characterizing substructure via mixture modeling in large-scale genetic summary statistics.American journal of human genetics · 2025Article
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- Sport-related concussion research agenda beyond medical science: culture, ethics, science, policy.Journal of medical ethics · 2024Article
- Epidemiologic study on prostate cancer in Sudanese men across African ethnic groups.Scientific reports · 2024Article
218 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
Quantifying patterns of population structure in Africans and African Americans illuminates the history of human populations and is critical for undertaking medical genomic studies on a global scale. To obtain a fine-scale genome-wide perspective of ancestry, we analyze Affymetrix GeneChip 500K genotype data from African Americans (n = 365) and individuals with ancestry from West Africa (n = 203 from 12 populations) and Europe (n = 400 from 42 countries). We find that population structure within the West African sample reflects primarily language and secondarily geographical distance, echoing the Bantu expansion. Among African Americans, analysis of genomic admixture by a principal component-based approach indicates that the median proportion of European ancestry is 18.5% (25th-75th percentiles: 11.6-27.7%), with very large variation among individuals. In the African-American sample as a whole, few autosomal regions showed exceptionally high or low mean African ancestry, but the X chromosome showed elevated levels of African ancestry, consistent with a sex-biased pattern of gene flow with an excess of European male and African female ancestry. We also find that genomic profiles of individual African Americans afford personalized ancestry reconstructions differentiating ancient vs. recent European and African ancestry. Finally, patterns of genetic similarity among inferred African segments of African-American genomes and genomes of contemporary African populations included in this study suggest African ancestry is most similar to non-Bantu Niger-Kordofanian-speaking populations, consistent with historical documents of the African Diaspora and trans-Atlantic slave trade.
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Registered trials
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