ArticleProceedings of the National Academy of Sciences of the United States of America2010
Actin polymerization driven mitochondrial transport in mating S. cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- The Mechanoreception inCells · 2023Article
- Hubbing the Cancer Cell.Cancers · 2022Review
- State ofInternational journal of molecular sciences · 2021Article
- Mitochondrial dynamics, positioning and function mediated by cytoskeletal interactions.Cellular and molecular life sciences : CMLS · 2021Review
- Ubl4A is critical for mitochondrial fusion process under nutrient deprivation stress.PloS one · 2020Article
- Weak Galilean invariance as a selection principle for coarse-grained diffusive models.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- In Mitochondria ?-Actin Regulates mtDNA Transcription and Is Required for Mitochondrial Quality Control.iScience · 2018Article
- Impact of dimensionality and network disruption on microrheology of cancer cells in 3D environments.PLoS computational biology · 2014Article
- Aip1p dynamics are altered by the R256H mutation in actin.Journal of visualized experiments : JoVE · 2014Article
- Inheritance of the fittest mitochondria in yeast.Trends in cell biology · 2014Review
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
The dynamic microenvironment of cells depends on macromolecular architecture, equilibrium fluctuations, and nonequilibrium forces generated by cytoskeletal proteins. We studied the influence of these factors on the motions of mitochondria in mating S. cerevisiae using Fourier imaging correlation spectroscopy (FICS). Our measurements provide detailed length-scale dependent information about the dynamic behavior of mitochondria. We investigate the influence of the actin cytoskeleton on mitochondrial motion and make comparisons between conditions in which actin network assembly and disassembly is varied either by using disruptive pharmacological agents or mutations that alter the rates of actin polymerization. Under physiological conditions, nonequilibrium dynamics of the actin cytoskeleton leads to 1.5-fold enhancement of the long-time mitochondrial diffusion coefficient and a transient subdiffusive temporal scaling of the mean-square displacement (MSD proportional, variant tau (alpha), with alpha = 2/3). We find that nonequilibrium forces associated with actin polymerization are a predominant factor in driving mitochondrial transport. Moreover, our results lend support to an existing model in which these forces are directly coupled to mitochondrial membrane surfaces.
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