ArticleProceedings of the National Academy of Sciences of the United States of America2010
Platform for in situ real-time measurement of protein-induced conformational changes of DNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Electronic control of DNA-based nanoswitches and nanodevices.Chemical science · 2016Article
- Entropy-driven collective interactions in DNA brushes on a biochip.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Sorting short fragments of single-stranded DNA with an evolving electric double layer.The journal of physical chemistry. B · 2013Article
- TATA binding proteins can recognize nontraditional DNA sequences.Biophysical journal · 2012Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A platform for in situ and real-time measurement of protein-induced conformational changes in dsDNA is presented. We combine electrical orientation of surface-bound dsDNA probes with an optical technique to measure the kinetics of DNA conformational changes. The sequence-specific Escherichia coli integration host factor is utilized to demonstrate protein-induced bending upon binding of integration host factor to dsDNA probes. The effects of probe surface density on binding/bending kinetics are investigated. The platform can accommodate individual spots of microarrayed dsDNA on individually controlled, lithographically designed electrodes, making it amenable for use as a high throughput assay.
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