ArticleProceedings of the National Academy of Sciences of the United States of America2010
Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Bayesian parameter estimation for dynamical models in systems biology.PLoS computational biology · 2022Article
- Stability Analysis of a Signaling Circuit with Dual Species of GTPase Switches.Bulletin of mathematical biology · 2021Article
- Plexin-Bs enhance their GAP activity with a novel activation switch loop generating a cooperative enzyme.Cellular and molecular life sciences : CMLS · 2021Article
- Two Complementary Signaling Pathways Depict Eukaryotic Chemotaxis: A Mechanochemical Coupling Model.Frontiers in cell and developmental biology · 2021Article
- Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway.Nutrients · 2020Article
- Article
- Extracting Diffusive States of Rho GTPase in Live Cells: Towards In Vivo Biochemistry.PLoS computational biology · 2015Article
- Signaling networks: information flow, computation, and decision making.Cold Spring Harbor perspectives in biology · 2015Review
- Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs.BMC systems biology · 2015Article
- Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses.Journal of the Royal Society, Interface · 2014Article
- Cancer stem cells: a systems biology view of their role in prognosis and therapy.Anti-cancer drugs · 2014Review
- Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Covalent modification cycles through the spatial prism.Biophysical journal · 2013Article
- Ultrasensitivity by molecular titration in spatially propagating enzymatic reactions.Biophysical journal · 2013Article
- Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.Cellular and molecular life sciences : CMLS · 2012Review
- An investigation of spatial signal transduction in cellular networks.BMC systems biology · 2012Article
- Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Analysis of the CYP1A1 mRNA dose-response in human keratinocytes indicates that relative potencies of dioxins, furans, and PCBs are species and congener specific.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cells often mount ultrasensitive (switch-like) responses to stimuli. The design principles underlying many switches are not known. We computationally studied the switching behavior of GTPases, and found that this first-order kinetic system can show ultrasensitivity. Analytical solutions indicate that ultrasensitive first-order reactions can yield switches that respond to signal amplitude or duration. The three-component GTPase system is analogous to the physical fermion gas. This analogy allows for an analytical understanding of the functional capabilities of first-order ultrasensitive systems. Experiments show amplitude- and time-dependent Rap GTPase switching in response to Cannabinoid-1 receptor signal. This first-order switch arises from relative reaction rates and the concentrations ratios of the activator and deactivator of Rap. First-order ultrasensitivity is applicable to many systems where threshold for transition between states is dependent on the duration, amplitude, or location of a distal signal. We conclude that the emergence of ultrasensitivity from coupled first-order reactions provides a versatile mechanism for the design of biochemical switches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.