ArticleProceedings of the National Academy of Sciences of the United States of America2010
Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferon-sensitive virus release through lipid rafts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- RNAViruses · 2026Review
- Real-Time PCR Assay to Quantify Moloney Murine Leukemia Virus in Mouse Cells.Microorganisms · 2025Article
- Article
- Exploring FeLV-Gag-Based VLPs as a New Vaccine Platform-Analysis of Production and Immunogenicity.International journal of molecular sciences · 2023Article
- Structural Domains of the Herpes Simplex Type 1 gD Protein that Restrict HIV-1 Particle Infectivity.Journal of virology · 2021Article
- Post-Translational Modifications of Retroviral HIV-1 Gag Precursors: An Overview of Their Biological Role.International journal of molecular sciences · 2021Review
- Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.FEMS microbiology reviews · 2019Review
- Effect of betulinic acid and its ionic derivatives on M-MuLV replication.Biochemical and biophysical research communications · 2018Article
- Ribosome profiling of the retrovirus murine leukemia virus.Retrovirology · 2018Article
- Article
- Analogies Between Cancer-Derived Extracellular Vesicles and Enveloped Viruses with an Emphasis on Human Breast Cancer.Current pathobiology reports · 2016Review
- Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms.Retrovirology · 2015Article
- N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.Journal of virology · 2015Article
- The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex.Journal of virology · 2014Article
- Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- HIV-1 Gag protein can sense the cholesterol and acyl chain environment in model membranes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Moloney murine leukemia virus glyco-gag facilitates xenotropic murine leukemia virus-related virus replication through human APOBEC3-independent mechanisms.Retrovirology · 2012Article
- Non-canonical translation in RNA viruses.The Journal of general virology · 2012Review
- The function and evolution of the restriction factor Viperin in primates was not driven by lentiviruses.Retrovirology · 2012Article
- Article
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4 authors.
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Abstract
Murine leukemia viruses encode a unique form of Gag polyprotein, gPr80gag or glyco-gag. Translation of this protein is initiated from full-length viral mRNA at an upstream initiation site in the same reading frame as Pr65(gag), the precursor for internal structural (Gag) proteins. Whereas gPr80gag is evolutionarily conserved among gammaretroviruses, its mechanism of action has been unclear, although it facilitates virus production at a late assembly or release step. Here, it is shown that gPr80gag facilitates release of Moloney murine leukemia virus (M-MuLV) from cells along an IFN-sensitive pathway. In particular, gPr80gag-facilitated release occurs through lipid rafts, because gPr80gag-negative M-MuLV has a lower cholesterol content, is less sensitive to inhibition of release by the cholesterol-depleting agent MbetaCD, and there is less Pr65gag associated with detergent-resistant membranes in mutant-infected cells. gPr80gag can also facilitate the release of HIV-1-based vector particles from human 293T cells.
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