ArticleJournal of autoimmunity2010
Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23.
Article in Journal of autoimmunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Oxidative Post-Translational Modifications of Insulin in Type 1 Diabetes Autoimmunity.Immunological reviews · 2026Review
- γδ T cells in diabetes mellitus: dual roles and therapeutic implications.Frontiers in immunology · 2025Review
- γδ T cells: origin and fate, subsets, diseases and immunotherapy.Signal transduction and targeted therapy · 2023Review
- A Distinctive γδ T Cell Repertoire in NOD Mice Weakens Immune Regulation and Favors Diabetic Disease.Biomolecules · 2022Article
- Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions.Cellular & molecular immunology · 2020Review
- Natural Self-Ligand Gamma Delta T Cell Receptors (γδTCRs) Insight: The Potential of Induced IgG.Vaccines · 2020Article
- IL-17Nature immunology · 2017Review
- A Special Connection between γδ T Cells and Natural Antibodies?Archivum immunologiae et therapiae experimentalis · 2016Review
- Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.PLoS pathogens · 2014Review
- γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.Molecular immunology · 2014Article
- Insights into the Relationship between Toll Like Receptors and Gamma Delta T Cell Responses.Frontiers in immunology · 2014Review
- Prevention or early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice.PloS one · 2014Article
- γδ T cells are essential effectors of type 1 diabetes in the nonobese diabetic mouse model.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Six-of-the-best: unique contributions of γδ T cells to immunology.Nature reviews. Immunology · 2013Review
- Diversity of γδ T-cell antigens.Cellular & molecular immunology · 2013Review
- T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice.Immunology · 2012Review
- Target specificity of an autoreactive pathogenic human γδ-T cell receptor in myositis.The Journal of biological chemistry · 2012Article
- Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes.The review of diabetic studies : RDS · 2012Review
- Article
- Peptide antigens for gamma/delta T cells.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The range and physical qualities of molecules that act as ligands for the gammadelta T cell receptors (TCRs) remain uncertain. Processed insulin is recognized by alphabeta T cells, which mediate diabetes in non-obese diabetic (NOD) mice. Here, we present evidence that gammadelta T cells in these mice recognize processed insulin as well. Hybridomas generated from NOD spleen and pancreatic lymph nodes included clones expressing gammadelta TCRs that responded specifically to purified islets of Langerhans and to an insulin peptide, but not to intact insulin. The gammadelta TCRs associated with this type of response are diverse, but a cloned gammadelta TCR was sufficient to transfer the response. The response to the insulin peptide was autonomous as demonstrated by stimulating single responder cells in isolation. This study reveals a novel specificity for gammadelta TCRs, and raises the possibility that gammadelta T cells become involved in islet-specific autoimmunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.