ArticleTrends in genetics : TIG2010
The strength of transcription-factor binding modulates co-variation in transcriptional networks.
Article in Trends in genetics : TIG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Single-cell dissection of aggression in honeybee colonies.Nature ecology & evolution · 2023Article
- Inference of Transcription Factor Regulation Patterns Using Gene Expression Covariation in Natural Populations ofBiophysics · 2018Article
- Analysis of variation at transcription factor binding sites in Drosophila and humans.Genome biology · 2012Article
- Transcriptional network structure has little effect on the rate of regulatory evolution in yeast.Molecular biology and evolution · 2012Article
- Learning transcriptional regulation on a genome scale: a theoretical analysis based on gene expression data.Briefings in bioinformatics · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
An appreciable fraction of the transcriptome differs in level of expression among individuals. Transcription factor (TF) expression and DNA binding causes cell-specific activation and repression of downstream targets, and TF expression levels vary across individuals. However, it is not clear how the strength of DNA binding for individual TFs translates into regulatory control, or whether a different set of binding motifs is used for strongly regulated modules. Here we integrate two publicly available data sets in Drosophila melanogaster, as well as conduct novel analyses, to address these questions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.