ArticleMolecular immunology2010
Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus.
Article in Molecular immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Article
- Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections.Open journal of immunology · 2012Article
- Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection.Infection and immunity · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
CD4 T cells selected by MHC class II expressing thymocytes (T-CD4 T cells) have distinct effector functions compared to that of epithelial cell-selected CD4 T cells (E-CD4 T cells). T-CD4 T cells produce both Th1 and Th2 effector cytokines immediately after stimulation and also express IL-4 in addition to IFN-gamma under the Th1 differentiation condition. In the present study, we investigated the capability of T-CD4 T cells to become IL-17-producing cells. We found that T-CD4 T cells express reduced IL-17 under Th17-inducing conditions. T-CD4 T cells express very low levels of receptor for TGF-beta and IL-21 that are essential to induce IL-17 expression. In addition, the induction of RORgammat, a key transcription factor for IL-17 gene expression, was compromised in T-CD4 T cells under Th17 skewing conditions and ectopic expression of RORgammat restored IL-17 expression. The defect of IL-17 and RORgammat expression in T-CD4 T cells is cell intrinsic and not due to effects of a secreted factor. Thus, the developmental pathway of CD4 T cells in the thymus plays a critical role in controlling an immune response by suppressing the generation of the Th17 lineage.
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