ReviewThe international journal of biochemistry & cell biology2011
Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells.
Review in The international journal of biochemistry & cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Dynamic assessment of a humanized bone tumour microenvironment reveals insights into osteosarcoma primary tumour remodelling and lung metastases.Scientific reports · 2025Article
- Cell therapy in end-stage liver disease: replace and remodel.Stem cell research & therapy · 2023Review
- Amniotic mesenchymal stem cells derived hepatocyte-like cells attenuated liver fibrosis more efficiently by mixed-cell transplantation.International journal of physiology, pathophysiology and pharmacology · 2020Article
- Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis.Journal of visualized experiments : JoVE · 2019Article
- Article
- Donor-derived hepatocytes in human hematopoietic cell transplant recipients: evidence of fusion.Virchows Archiv : an international journal of pathology · 2019Article
- Alcoholic liver disease: Utility of animal models.World journal of gastroenterology · 2018Review
- Cells responsible for liver mass regeneration in rats with 2-acetylaminofluorene/partial hepatectomy injury.Journal of biomedical science · 2018Article
- Insulin-like growth factor 2 is a key mitogen driving liver repopulation in mice.Cell death & disease · 2018Article
- Wilson's disease: Prospective developments towards new therapies.World journal of gastroenterology · 2017Review
- Experimental Model for Successful Liver Cell Therapy by Lenti TTR-YapERT2 Transduced Hepatocytes with Tamoxifen Control of Yap Subcellular Location.Scientific reports · 2016Article
- Role of radiotherapy in the management of hepatocellular carcinoma: A systematic review.World journal of hepatology · 2015Review
- Cell therapy to remove excess copper in Wilson's disease.Annals of the New York Academy of Sciences · 2014Review
- Cellular therapy for liver disease.Mayo Clinic proceedings · 2014Review
- Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice.The American journal of pathology · 2014Article
- Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Human Liver Progenitor Cells for Liver Repair.Cell medicine · 2013Review
- Rodent models of alcoholic liver disease: of mice and men.Alcohol (Fayetteville, N.Y.) · 2012Review
- Generation of functional hepatic cells from pluripotent stem cells.Journal of stem cell research & therapy · 2012Article
- Model systems and clinical applications of hepatic stem cells for liver regeneration.Hepatology international · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In recent years, there has been substantial progress in transplanting cells into the liver with the ultimate goal of restoring liver mass and function in both inherited and acquired liver diseases. The basis for considering that this might be feasible is that the liver is a highly regenerative organ. After massive liver injury or surgical removal of two-thirds or more of the liver tissue, the organ can restore its mass with completely normal morphologic structure and function. It has also been found under highly selective conditions that transplanted hepatocytes can fully repopulate the liver and cure a metabolic disorder or deficiency state. Fetal liver cells can also substantially repopulate the normal liver, and it is hoped in the future that effective repopulation will be achievable with cultured cells or cell lines, pluripotent stem cells from other somatic tissues, embryonic stem cells, or induced pluripotent stem cells, which can now be generated in vitro by a variety of methods. The purpose of this review is to present the major systems that have been used for liver repopulation, the variables involved in obtaining successful repopulation and what has been achieved in these various systems to date with different cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.