ArticleGastroenterology2010
The risk of esophageal adenocarcinoma after antireflux surgery.
Article in Gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 73 citations in OpenAlex.
- LAPAROSCOPIC ANTIREFLUX SURGERY: ARE OLD QUESTIONS ANSWERED? SHOULD IT BE USED CONJOINED WITH ENDOSCOPIC THERAPY FOR BARRETT'S ESOPHAGUS?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022Article
- Esophageal cancer: Epidemiology, risk factors and screening.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021Article
- Review
- Development and Evaluation of Serum CST1 Detection for Early Diagnosis of Esophageal Squamous Cell Carcinoma.Cancer management and research · 2021Article
- Risk of Esophageal Adenocarcinoma After Antireflux Surgery in Patients With Gastroesophageal Reflux Disease in the Nordic Countries.JAMA oncology · 2018Article
- Does anti-reflux surgery disrupt the pathway of Barrett's esophagus progression to cancer?Translational gastroenterology and hepatology · 2018Review
- Current Concepts in Treatment of Barrett's Esophagus With and Without Dysplasia.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Review
- From Heartburn to Barrett's Esophagus, and Beyond.World journal of surgery · 2017Review
- Trends in esophageal and esophagogastric junction cancer research from 2007 to 2016: A bibliometric analysis.Medicine · 2017Review
- BOB CAT: A Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia.The American journal of gastroenterology · 2015Review
- Optimizing Patient Selection and Outcomes for Surgical Treatment of GERD and Achalasia.Current treatment options in gastroenterology · 2015Article
- Identification of glutathione S-transferase omega 1 (GSTO1) protein as a novel tumor-associated antigen and its autoantibody in human esophageal squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Esophageal cancer in Canada: trends according to morphology and anatomical location.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012Article
- [Clinical aspects of premalignant lesions of the upper gastrointestinal tract].Der Pathologe · 2011Review
- [No cancer prevention with fundoplication : Results of a population-based study in Sweden].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2011Article
- Treatment of GERD complications (Barrett's, peptic stricture) and extra-oesophageal syndromes.Best practice & research. Clinical gastroenterology · 2010Review
- Long-term follow-up after anti-reflux surgery in patients with Barrett's esophagus.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Article
- Pathophysiology and treatment of Barrett's esophagus.World journal of gastroenterology · 2010Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsThe question of a possible preventive effect of antireflux surgery on the development of esophageal or cardia adenocarcinoma remains unsettled. We aimed to clarify whether antireflux surgery prevents later development of esophageal adenocarcinoma.
methodsWe performed a Swedish population-based cohort study of antireflux surgery from 1965 to 2006. Follow-up evaluation for cancer and censoring for death and emigration were achieved up to December 31, 2006, through linkages to nationwide registers of cancer, population, and emigration. The cancer incidence in the antireflux surgery cohort was compared with that in the corresponding Swedish population. Relative risks were presented as standardized incidence ratios (SIRs), that is, the observed number of cancer cases in the antireflux surgery cohort divided by the expected number.
resultsThe antireflux surgery cohort comprised 14,102 persons, contributing 120,514 person-years at risk. Overall risk of esophageal adenocarcinoma (n = 39) was increased 12-fold (SIR, 12.3; 95% confidence interval [CI], 8.7-16.8). No risk decrease with time after antireflux surgery was found (P = .86). After a postsurgical follow-up evaluation of 15 years or more, the SIR was 14.6 (95% CI, 7.0-26.8). For the corresponding overall risk of cardia adenocarcinoma (n = 21) the SIR was 4.4 (95% CI, 2.7-6.7), without any major decrease in risk with time (P = .20); the SIR was 3.1 (95% CI, 0.6-9.1) after at least 15 years of follow-up evaluation. No association between antireflux surgery and gastric adenocarcinoma or esophageal squamous cell carcinoma was identified.
conclusionsAntireflux surgery cannot be considered to prevent the development of esophageal or cardia adenocarcinoma among persons with reflux.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.