ReviewCurrent opinion in pharmacology2010
Electrophilic nitro-fatty acids: anti-inflammatory mediators in the vascular compartment.
Review in Current opinion in pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Nitro-Oleic Acid (NOInternational journal of molecular sciences · 2021Article
- Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation.Innate immunity · 2021Article
- A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity.Redox biology · 2021Article
- Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis.Scientific reports · 2020Article
- Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells.Physiological genomics · 2019Article
- Post-Translational Modification of Proteins Mediated by Nitro-Fatty Acids in Plants: Nitroalkylation.Plants (Basel, Switzerland) · 2019Review
- A novel nitroalkene-α-tocopherol analogue inhibits inflammation and ameliorates atherosclerosis in Apo E knockout mice.British journal of pharmacology · 2019Article
- Inflammatory signaling and metabolic regulation by nitro-fatty acids.Nitric oxide : biology and chemistry · 2018Review
- Nitro-oleic acid inhibits vascular endothelial inflammatory responses and the endothelial-mesenchymal transition.Biochimica et biophysica acta · 2016Article
- Protection of nitro-fatty acid against kidney diseases.American journal of physiology. Renal physiology · 2016Review
- Nitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms.Frontiers in bioscience (Landmark edition) · 2016Review
- Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis.BioMed research international · 2016Review
- Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog.Redox biology · 2015Article
- Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation.Antioxidants & redox signaling · 2014Article
- Influence of nutrition in PCB-induced vascular inflammation.Environmental science and pollution research international · 2014Review
- Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid.Free radical biology & medicine · 2014Article
- Combined losartan and nitro-oleic acid remarkably improves diabetic nephropathy in mice.American journal of physiology. Renal physiology · 2013Article
- Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine.Journal of lipid research · 2013Article
- Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts.Cardiovascular research · 2013Article
- Heme oxygenase-1, oxidation, inflammation, and atherosclerosis.Frontiers in pharmacology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Vascular inflammatory disorders are often associated with both decreased NO bioavailability and a lack of responsiveness to NO, a consequence of impaired NO biosynthesis, dysregulated l-arginine metabolism, endothelial nitric oxide synthase (eNOS) uncoupling and NO consumption induced by redox reactions of NO. The latter is mediated via oxidative inflammatory conditions altering NO-dependent endothelial function, including vascular tone and cell proliferation. The redox reactions of NO and byproducts such as nitrite can react to yield electrophilic nitro-fatty acid derivatives (NO(2)-FAs) and exemplify a biochemical convergence of reactions participating in NO and lipid signaling. NO(2)-FAs represent a novel therapeutic strategy to treat vascular disorders by improving endothelial dysfunction through enhancing NO signaling and blocking vascular smooth muscle proliferation, inflammation, and maladaptive remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.