ArticleDrug and alcohol dependence2010
Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints.
Article in Drug and alcohol dependence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 109 citations in OpenAlex.
- Sleep reductions associated with illicit opioid use and clinic-hour changes during opioid agonist treatment for opioid dependence: Measurement by electronic diary and actigraphy.Journal of substance abuse treatment · 2019Trial
- Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial.Drug and alcohol dependence · 2012Trial
- Latent classes of sleep deficiency and correlates among patients receiving methadone treatment: A longitudinal study.Addiction (Abingdon, England) · 2026Article
- Quality of Sleep and Related Factors in Individuals Undergoing Methadone Maintenance Treatment.Addiction & health · 2025Article
- Article
- Cerebral blood flow in the paracentral lobule is associated with poor subjective sleep quality among patients with a history of methadone maintenance treatment.Frontiers in neurology · 2024Article
- Methadone Dose and Timing of Administration as Predictors of Sleep Apnea Syndrome During Methadone Maintenance Treatment: A Retrospective Cross-sectional Study.Addiction & health · 2023Article
- Central Sleep Apnea in Adults: Diagnosis and Treatment.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023Article
- Editorial: Application and evaluation of acupuncture in the treatment of neurological diseases.Frontiers in neurology · 2023Article
- Opioids and obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Review
- Poor Sleep Quality and Other Risk Factors for Unemployment Among Patients on Opioid Agonist Treatment.Substance abuse : research and treatment · 2022Article
- Decision tree model based prediction of the efficacy of acupuncture in methadone maintenance treatment.Frontiers in neurology · 2022Article
- A review of sleep disturbance in adults prescribed medications for opioid use disorder: potential treatment targets for a highly prevalent, chronic problem.Sleep medicine · 2021Review
- Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment.Sleep & breathing = Schlaf & Atmung · 2020Article
- Crosstalk between Sleep Disturbance and Opioid Use Disorder: A Narrative Review.Addiction & health · 2020Review
- Prolonged Sleep Apnea in Two Patients with a History of Opium Abuse -A Case Report.Iranian journal of otorhinolaryngology · 2020Article
- Chronic Opioid Therapy and Sleep: An American Academy of Sleep Medicine Position Statement.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan.Neuropsychiatric disease and treatment · 2018Article
- Chronic Opioid Use Following Surgery for Oral Cavity Cancer.JAMA otolaryngology-- head & neck surgery · 2017Article
- Opioids and Chronic Pain: Where Is the Balance?Current oncology reports · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesOpioid-dependent patients treated with methadone have subjective sleep complaints and disrupted sleep on polysomnography (PSG). Previous studies of sleep-disordered breathing (SDB) in this population have focused on central sleep apnea (CSA). Our objectives were to: (1) characterize obstructive sleep apnea (OSA) and CSA in patients in methadone maintenance treatment (MMT) for opioid dependence; (2) examine factors associated with SDB in this population; and (3) investigate whether SDB was related to severity of subjective sleep complaints in MMT patients with subjective sleep disturbances.
methodsWe analyzed OSA and CSA from one night of home PSG in 71 patients who were in MMT for at least 3 months and had a Pittsburgh Sleep Quality Inventory (PSQI) score >5.
resultsOSA (defined as obstructive apnea-hypopnea index (OAHI) > or = 5) was observed in 35.2% of our sample. OSA was associated with higher body mass index, longer duration in MMT, and non-Caucasian race. CSA (defined as central apnea index (CAI) > or = 5) was observed in 14.1% of the sample. CSA was not associated with methadone dose or concomitant drug use. Subjective sleep disturbance measured with the PSQI was not related to OSA or CSA.
conclusionsSDB was common in this sample of MMT patients and OSA was more common than CSA. Given the lack of association between presence of SDB and severity of subjective sleep difficulties, factors other than sleep apnea must account for complaints of disturbed sleep in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.