ArticleCurrent biology : CB2010
A cellular memory of developmental history generates phenotypic diversity in C. elegans.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 131 citations in OpenAlex.
- Mating strategies in Caenorhabditis elegans populations are determined by male developmental history.G3 (Bethesda, Md.) · 2026Article
- The sleeping threat: targeting cancer dormancy to transform metastasis therapy.Nature reviews. Cancer · 2026Review
- Gap junctions in the alimentary tract regulate reproductive span inbioRxiv : the preprint server for biology · 2026Article
- The impact of rearing environment on C. elegans: phenotypic, transcriptomic and intergenerational responses to 3D enriched habitats.Biology open · 2026Article
- Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the Caenorhabditis elegans germ line.Development (Cambridge, England) · 2026Article
- AMPK modulates a DEAH box RNA-helicase to attenuate TOR signaling and establish developmental quiescence in Caenorhabditis elegans.PLoS biology · 2025Article
- From Worms to Tumors: Conserved Strategies of Cellular Arrest and Survival Governing Dormancy.Cancer research · 2025Review
- Age Deceleration and Reversal Gene Patterns in Dauer Diapause.Aging cell · 2025Article
- Developmental plasticity of hermaphrodite sperm production across environments in Caenorhabditis elegans.PloS one · 2025Article
- Unifying fragmented perspectives with additive deep learning for high-dimensional models from partial faceted datasets.npj biological physics and mechanics · 2025Article
- The many roads toJournal of biosciences · 2025Review
- Robustness and variability inbioRxiv : the preprint server for biology · 2024Article
- Dauer juvenile recovery transcriptome of two contrasting EMS mutants of the entomopathogenic nematode Heterorhabditis bacteriophora.World journal of microbiology & biotechnology · 2024Article
- Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin.Science advances · 2024Article
- RNAi-dependent expression of sperm genes in ADL chemosensory neurons is required for olfactory responses inFrontiers in molecular biosciences · 2024Article
- Transcriptional and spatiotemporal regulation of the dauer program.Transcription · 2023Review
- Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway.PLoS genetics · 2023Article
- EGFR signal transduction is downregulated in C. elegans vulval precursor cells during dauer diapause.Development (Cambridge, England) · 2022Article
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7 more citing papers are in PubMed but not listed here.
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5 authors at 2 institutions in 1 country.
Funding
Abstract
Early life experiences have a major impact on adult phenotypes [1-3]. However, the mechanisms by which animals retain a cellular memory of early experience are not well understood. Here we show that adult wild-type Caenorhabditis elegans that transiently pass through the stress-resistant dauer larval stage exhibit distinct gene expression profiles and life history traits, as compared to adult animals that bypassed this stage. Using chromatin immunoprecipitation experiments coupled with massively parallel sequencing, we found that genome-wide levels of specific histone tail modifications are markedly altered in postdauer animals. Mutations in subsets of genes implicated in chromatin remodeling abolish, or alter, the observed changes in gene expression and life history traits in postdauer animals. Modifications to the epigenome as a consequence of early experience may contribute in part to a memory of early experience and generate phenotypic variation in an isogenic population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.