Evidence map›Paper›PMID 20079451›Full record

ReviewSeminars in cell & developmental biology2010

Organellar vs cellular control of mitochondrial dynamics.

Brigham B Hyde, Gilad Twig, Orian S Shirihai

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
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  7. Review
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  17. Review
  18. Review
  19. Mitochondria in lung diseases.Expert review of respiratory medicine · 2013
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Brigham B HydeDepartment of Medicine, Boston University Medical Center, Boston, MA 02118, USA.
Gilad Twig
Orian S Shirihai
University Medical Center · USBoston University · US

Funding

Mitochondrial dynamics in beta cell function and dysfunctionR01DK074778 · NIDDK · TUFTS UNIVERSITY BOSTON · PI CORKEY, BARBARA E., SHIRIHAI, ORIAN S · 2007 to 2015
$3.5M
Erythroid transporter function in hemoglobin synthesisR01HL071629 · NHLBI · TUFTS UNIVERSITY BOSTON · PI SHIRIHAI, ORIAN S · 2003 to 2007
$1.4M
NHLBI NIH HHS R01 HL071629NIDDK NIH HHS R01 DK074778
6 · The paper itself

Abstract

Mitochondrial dynamics, the fusion and fission of individual mitochondrial units, is critical to the exchange of the metabolic, genetic and proteomic contents of individual mitochondria. In this regard, fusion and fission events have been shown to modulate mitochondrial bioenergetics, as well as several cellular processes including fuel sensing, ATP production, autophagy, apoptosis, and the cell cycle. Regulation of the dynamic events of fusion and fission occur at two redundant and interactive levels. Locally, the microenvironment of the individual mitochondrion can alter its ability to fuse, divide or move through the cell. Globally, nuclear-encoded processes and cellular ionic and second messenger systems can alter or activate mitochondrial proteins, regulate mitochondrial dynamics and concomitantly change the condition of the mitochondrial population. In this review we investigate the different global and local signals that control mitochondrial biology. This discussion is carried out to clarify the different signals that impact the status of the mitochondrial population.

Indexed as

Cell CycleDNA, MitochondrialMembrane FusionMitochondriaMitochondrial ProteinsDNA, MitochondrialMitochondrial Proteins

Identifiers

PMID20079451
PMCPMC3808978
OpenAlexW2009190773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.