ArticleBrain research2010
Muscarinic receptor activation modulates the excitability of hilar mossy cells through the induction of an afterdepolarization.
Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer's disease.Frontiers in dementia · 2025Review
- Muscarinic acetylcholine receptor activated effectors in principal neurons of the rat basolateral amygdala.Frontiers in cellular neuroscience · 2025Article
- Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells.eLife · 2023Article
- Assessments of dentate gyrus function: discoveries and debates.Nature reviews. Neuroscience · 2023Review
- A synaptic signal for novelty processing in the hippocampus.Nature communications · 2022Article
- Early changes in synaptic and intrinsic properties of dentate gyrus granule cells in a mouse model of Alzheimer's disease neuropathology and atypical effects of the cholinergic antagonist atropine.Neurobiology of disease · 2021Article
- Dentate Gyrus Mossy Cells Share a Role in Pattern Separation with Dentate Granule Cells and Proximal CA3 Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The enigmatic mossy cell of the dentate gyrus.Nature reviews. Neuroscience · 2016Review
- Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit.Frontiers in synaptic neuroscience · 2016Review
- Regulation of persistent activity in hippocampal mossy cells by inhibitory synaptic potentials.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons.Frontiers in cellular neuroscience · 2014Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In the present study we used electrophysiological techniques in an in vitro preparation of the rat dentate gyrus to examine the effect of muscarinic acetylcholine receptor activation on the intrinsic excitability of hilar neurons. We found that bath application of muscarine caused a direct depolarization in approximately 80% of mossy cells tested, and also produced a clear afterdepolarization (ADP) in nearly 100% of trials. The ADP observed in hilar mossy cells is produced by the opening of a Na(+) permeant and yet largely TTX insensitive ion channel. It requires an increase in postsynaptic calcium for activation, and is blocked by flufenamic acid, an antagonist of a previously identified calcium activated non-selective cation channel (I(CAN)). Further, we demonstrate that induction of an ADP in current clamp causes release of cannabinoids, and subsequent depression of GABAergic transmission that is comparable to that produced in the same cells by a more conventional 5s depolarization in voltage clamp. By contrast, other types of hilar neurons were less strongly depolarized by bath application of muscarinic agonists, and uniformly lacked a similar muscarinic ADP. Overall, the data presented here extend our understanding of the specific mechanisms through which muscarinic agonists are likely to modulate neuronal excitability in the hilar network, and further reveal a mechanism that could plausibly promote endocannabinoid mediated signaling in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.