ArticleBMC genomics2010
Evolution of electron transfer out of the cell: comparative genomics of six Geobacter genomes.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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95 citing papers in PubMed, 211 citations in OpenAlex.
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- Adjusted bacterial cooperation in anammox community to adapt to high ammonium in wastewater treatment plant.Water research X · 2024Article
- A survey of the Desulfuromonadia "cytochromome" provides a glimpse of the unexplored diversity of multiheme cytochromes in nature.BMC genomics · 2024Article
- Novel Insights on Extracellular Electron Transfer Networks in theMicroorganisms · 2024Article
- Periplasmic electron transfer network in Geobacter sulfurreducens revealed by biomolecular interaction studies.Protein science : a publication of the Protein Society · 2024Article
- Metaproteomic and Metagenomic-Coupled Approach to Investigate Microbial Response to Electrochemical Conditions in Microbial Fuel Cells.Microorganisms · 2023Article
- Methane production bymBio · 2023Article
- A Biochemical Deconstruction-Based Strategy to Assist the Characterization of Bacterial Electric Conductive Filaments.International journal of molecular sciences · 2023Article
- Polyphasic Characterization ofMicroorganisms · 2023Article
- Active anaerobic methane oxidation and sulfur disproportionation in the deep terrestrial subsurface.The ISME journal · 2022Article
- Biotechnological synthesis of Pd-based nanoparticle catalysts.Nanoscale advances · 2022Review
- Cytochrome OmcS Is Not Essential for Extracellular Electron Transport via Conductive Pili in Geobacter sulfurreducens Strain KN400.Applied and environmental microbiology · 2022Article
35 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGeobacter species grow by transferring electrons out of the cell--either to Fe(III)-oxides or to man-made substances like energy-harvesting electrodes. Study of Geobacter sulfurreducens has shown that TCA cycle enzymes, inner-membrane respiratory enzymes, and periplasmic and outer-membrane cytochromes are required. Here we present comparative analysis of six Geobacter genomes, including species from the clade that predominates in the subsurface. Conservation of proteins across the genomes was determined to better understand the evolution of Geobacter species and to create a metabolic model applicable to subsurface environments.
resultsThe results showed that enzymes for acetate transport and oxidation, and for proton transport across the inner membrane were well conserved. An NADH dehydrogenase, the ATP synthase, and several TCA cycle enzymes were among the best conserved in the genomes. However, most of the cytochromes required for Fe(III)-reduction were not, including many of the outer-membrane cytochromes. While conservation of cytochromes was poor, an abundance and diversity of cytochromes were found in every genome, with duplications apparent in several species.
conclusionsThese results indicate there is a common pathway for acetate oxidation and energy generation across the family and in the last common ancestor. They also suggest that while cytochromes are important for extracellular electron transport, the path of electrons across the periplasm and outer membrane is variable. This combination of abundant cytochromes with weak sequence conservation suggests they may not be specific terminal reductases, but rather may be important in their heme-bearing capacity, as sinks for electrons between the inner-membrane electron transport chain and the extracellular acceptor.
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