ArticleArthritis research & therapy2010
Chronic arthritis leads to disturbances in the bone collagen network.
Article in Arthritis research & therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 35 citations in OpenAlex.
- Spatial polarimetric second harmonic generation evaluation of collagen in a hypophosphatasia mouse model.Biomedical optics express · 2024Article
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- Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging.Frontiers in bioengineering and biotechnology · 2021Article
- Second harmonic generation characterization of collagen in whole bone.Biomedical optics express · 2020Article
- Signalling Alterations in Bones of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Gene Deficient Mice.International journal of molecular sciences · 2018Article
- Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice.Scientific reports · 2018Article
- Article
- Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis.Disease models & mechanisms · 2017Article
- Autoimmune arthritis deteriorates bone quantity and quality of periarticular bone in a mouse model of rheumatoid arthritis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures.International journal of endocrinology · 2017Article
- The Impact of Conventional and Biological Disease Modifying Antirheumatic Drugs on Bone Biology. Rheumatoid Arthritis as a Case Study.Clinical reviews in allergy & immunology · 2016Review
- Arthritis induces early bone high turnover, structural degradation and mechanical weakness.PloS one · 2015Article
- Rheumatoid arthritis bone fragility is associated with upregulation of IL17 and DKK1 gene expression.Clinical reviews in allergy & immunology · 2014Article
- Systemic but no local effects of combined zoledronate and parathyroid hormone treatment in experimental autoimmune arthritis.PloS one · 2014Article
- SKG arthritis as a model for evaluating therapies in rheumatoid arthritis with special focus on bone changes.Rheumatology international · 2013Article
- Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function.The Journal of clinical investigation · 2012Article
- Smoking is a predictor of worse trabecular mechanical performance in hip fragility fracture patients.Journal of bone and mineral metabolism · 2012Article
- Bone formation and resorption are both increased in experimental autoimmune arthritis.PloS one · 2012Article
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn this study we used a mice model of chronic arthritis to evaluate if bone fragility induced by chronic inflammation is associated with an imbalance in bone turnover and also a disorganization of the bone type I collagen network.
methodsSerum, vertebrae and femur bones were collected from eight-month-old polyarthritis SKG mice and controls. Strength of the femoral bones was evaluated using three-point bending tests and density was assessed with a pycnometer. Bone turnover markers carboxy-terminal collagen cross-linking telopeptides (CTX-I) and amino-terminal propeptide of type I procollagen (PINP) were measured in serum. The organization and density of bone collagen were analyzed in vertebrae using second-harmonic generation (SHG) imaging with a two-photon microscope and trabecular bone microstructure was assessed by scanning electron microscope (SEM).
resultsFemoral bones of SKG mice revealed increased fragility expressed by deterioration of mechanical properties, namely altered stiffness (P = 0.007) and reduced strength (P = 0.006), when compared to controls. Accordingly, inter-trabecular distance and trabecular thickness as observed by SEM were reduced in SKG mice. PINP was significantly higher in arthritic mice (9.18 +/- 3.21 ng/ml) when compared to controls (1.71 +/- 0.53 ng/ml, P < 0.001). Bone resorption marker CTX-I was 9.67 +/- 3.18 ng/ml in arthritic SKG mice compared to 6.23 +/- 4.11 ng/ml in controls (P = 0.176). The forward-to-backward signal ratio measured by SHG was higher in SKG animals, reflecting disorganized matrix and loose collagen structure, compared to controls.
conclusionsWe have shown for the first time that chronic arthritis by itself impairs bone matrix architecture, probably due to disturbed bone remodeling and increased collagen turnover. This effect might predispose patients to bone fragility fractures.
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