ArticleMolecular plant pathology2010
PR10 expression in maize and its effect on host resistance against Aspergillus flavus infection and aflatoxin production.
Article in Molecular plant pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Resistance of Transgenic Maize Cultivars to Mycotoxin Production-Systematic Review and Meta-Analysis.Toxins · 2024Pooled it
- Molecular mechanism of ZmWRKY36 mediated maize resistance to Bipolaris maydis.BMC plant biology · 2026Article
- Review
- Mycotoxin toxicity and its alleviation strategy on female mammalian reproduction and fertility.Journal of advanced research · 2025Review
- Host-Induced Gene Silencing of theToxins · 2024Article
- Heterologous expression of Halostachys caspica pathogenesis-related protein 10 increases salt and drought resistance in transgenic Arabidopsis thaliana.Plant molecular biology · 2024Article
- Article
- Targeting theFrontiers in plant science · 2023Article
- Revealing the contribution of GbPR10.5D1 to resistance against Verticillium dahliae and its regulation for structural defense and immune signaling.The plant genome · 2022Article
- Comparative Analysis of Multiple GWAS Results Identifies Metabolic Pathways Associated with Resistance toToxins · 2022Article
- Genome-Wide Association Mapping of Crown and Brown Rust Resistance in Perennial Ryegrass.Genes · 2021Article
- Enzymatic degradation is an effective means to reduce aflatoxin contamination in maize.BMC biotechnology · 2021Article
- Resistance to Aflatoxin Accumulation in Maize Mediated by Host-Induced Silencing of theJournal of fungi (Basel, Switzerland) · 2021Article
- Comparative transcriptome profiling and co-expression network analysis uncover the key genes associated withearly-stage resistance to Aspergillus flavus in maize.BMC plant biology · 2021Article
- Host Induced Gene Silencing TargetingFrontiers in microbiology · 2020Article
- A Pathogenesis-Related Protein-Like Gene Is Involved in theFrontiers in plant science · 2020Article
- Influence of Wounding and Temperature on Resistance of Maize Landraces From Mexico to Aflatoxin Contamination.Frontiers in plant science · 2020Article
- Use of Dual RNA-seq for Systems Biology Analysis ofFrontiers in microbiology · 2020Article
- Functional Biology and Molecular Mechanisms of Host-Pathogen Interactions for Aflatoxin Contamination in Groundnut (Frontiers in microbiology · 2020Review
- Proteases Underground: Analysis of the Maize Root Apoplast Identifies Organ Specific Papain-Like Cysteine Protease Activity.Frontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maize (Zea mays L.) is a major crop susceptible to Aspergillus flavus infection and subsequent contamination with aflatoxins, the potent carcinogenic secondary metabolites of the fungus. Protein profiles of maize genotypes resistant and susceptible to A. flavus infection and/or aflatoxin contamination have been compared, and several resistance-associated proteins have been found, including a pathogenesis-related protein 10 (PR10). In this study, RNA interference (RNAi) gene silencing technology was employed to further investigate the importance of PR10. An RNAi gene silencing vector was constructed and introduced into immature Hi II maize embryos through both bombardment and Agrobacterium infection procedures. PR10 expression was reduced by 65% to more than 99% in transgenic callus lines from bombardment. The RNAi-silenced callus lines also showed increased sensitivity to heat stress treatment. A similar reduction in PR10 transcript levels was observed in seedling leaf and root tissues developed from transgenic kernels. When inoculated with A. flavus, RNAi-silenced mature kernels produced from Agrobacterium-mediated transformation showed a significant increase in fungal colonization and aflatoxin production in 10 and six, respectively, of 11 RNAi lines compared with the non-silenced control. Further proteomic analysis of RNAi-silenced kernels revealed a significant reduction in PR10 production in eight of 11 RNAi lines that showed positive for transformation. A significant negative correlation between PR10 expression at either transcript or protein level and kernel aflatoxin production was observed. The results indicate a major role for PR10 expression in maize aflatoxin resistance.
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