ArticleMovement disorders : official journal of the Movement Disorder Society2010
Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders.
Article in Movement disorders : official journal of the Movement Disorder Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Parkinsonian signs and cognitive trajectories in older adults: a population-based longitudinal study.Age and ageing · 2026Article
- 3D Kinematics Quantifies Gait Response to Levodopa earlier and to a more Comprehensive Extent than the MDS-Unified Parkinson's Disease Rating Scale in Patients with Motor Complications.Movement disorders clinical practice · 2024Article
- Effects of Cerebrovascular and Lewy Body Pathology on Parkinsonian Signs in Community-Dwelling Older Adults.Neurology · 2023Article
- Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment.BMC geriatrics · 2023Article
- Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study.BMC neurology · 2023Article
- Predictive power of gait and gait-related cognitive measures in amnestic mild cognitive impairment: a machine learning analysis.Frontiers in human neuroscience · 2023Article
- Association of Statins With Cerebral Atherosclerosis and Incident Parkinsonism in Older Adults.Neurology · 2022Article
- Mild Parkinsonian Signs, Energy Decline, and Striatal Volume in Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Risk of mild cognitive impairment among older adults in the United States by ethnoracial group.International psychogeriatrics · 2021Article
- Cardiovascular Metrics Associated With Prevention of Aging-Related Parkinsonian Signs Following Exercise Intervention in Sedentary Older Rats.Frontiers in aging neuroscience · 2021Article
- Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults.PloS one · 2021Article
- Clinical and neuroimaging correlates of progression of mild parkinsonian signs in community-dwelling older adults.Parkinsonism & related disorders · 2020Article
- Total Daily Physical Activity and the Risk of Parkinsonism in Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Predictors for Incident Mild Parkinsonian Signs in Older Japanese.Yonago acta medica · 2020Article
- Article
- CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Inventory of real world data sources in Parkinson's disease.BMC neurology · 2017Review
- Motor Abnormalities: From Neurodevelopmental to Neurodegenerative Through "Functional" (Neuro)Psychiatric Disorders.Schizophrenia bulletin · 2017Review
- Subtle motor disturbances in PREDICT-PD participants.Journal of neurology, neurosurgery, and psychiatry · 2017Article
- Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs.Alzheimer's research & therapy · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community-dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow-up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) = 2.24 (P< 0.001), adjusted HR = 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HR(axial dysfunction) = 2.45 (P < 0.001), adjusted HR(tremor) = 2.38 (P = 0.006), and adjusted HR(rigidity) = 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E-e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.