ArticleBreast cancer research and treatment2010
Medical comorbidities predict mortality in women with a history of early stage breast cancer.
Article in Breast cancer research and treatment, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC).Cancer causes & control : CCC · 2016Pooled it
- Impact of a behavioral weight loss intervention on comorbidities in overweight and obese breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Trial
- Barriers and facilitators to recruitment to a culturally-based dietary intervention among urban Hispanic breast cancer survivors.Journal of racial and ethnic health disparities · 2015Trial
- Associations of soluble fiber, whole fruits/vegetables, and juice with plasma Beta-carotene concentrations in a free-living population of breast cancer survivors.Women & health · 2012Trial
- Comorbidities And Reducing InEquitieS (CARES): Feasibility of self-monitoring and community health worker support in management of comorbidities among Black breast and prostate cancer patients.Contemporary clinical trials communications · 2025Article
- Relationship between Survival Days, Cancer Cachexia, and Activities of Daily Living in Palliative Cancer Patients Undergoing Rehabilitation.Progress in rehabilitation medicine · 2024Article
- Caregivers with Cancer Patients: Focus on Hispanics.Cancers · 2023Review
- Obesity: An Independent Risk Factor for Complications in Anterior Lumbar Interbody Fusion? A Systematic Review.Global spine journal · 2022Article
- Evaluating and Balancing the Risk of Breast Cancer-Specific Death and Other Cause-Specific Death in Elderly Breast Cancer Patients.Frontiers in oncology · 2021Article
- Improving health engagement and lifestyle management for breast cancer survivors with diabetes.Contemporary clinical trials · 2020Article
- Endocrine Therapy-related Endocrinopathies-Biology, Prevalence and Implications for the Management of Breast Cancer.Oncology & hematology review · 2020Article
- The effect of modifiable risk factors on breast cancer aggressiveness among black and white women.American journal of surgery · 2019Article
- Breast Cancer Screening Participation of Women with Chronic Diseases in Korea: Analysis of the 2012 Korean National Health and Nutrition Examination SurveyAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Fructosamine and diabetes as predictors of mortality among Hispanic and non-Hispanic white breast cancer survivors.NPJ breast cancer · 2019Article
- Good glycaemic control is associated with a better prognosis in breast cancer patients with type 2 diabetes mellitus.Clinical and experimental medicine · 2018Article
- The associations of comorbidities and consumption of fruit and vegetable with quality of life among stomach cancer survivors.Health and quality of life outcomes · 2018Article
- Observational
- Sleep duration and breast cancer prognosis: perspectives from the Women's Healthy Eating and Living Study.Breast cancer research and treatment · 2017Article
- Article
- Diabetes and breast cancer mortality in Black women.Cancer causes & control : CCC · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
This analysis was conducted to determine whether comorbid medical conditions predict additional breast cancer events and all-cause mortality in women with a history of early stage breast cancer. Women (n = 2,542) participating in a randomized diet trial completed a self-administered questionnaire regarding whether they were currently being treated for a wide variety of diseases (cardiovascular, diabetes, gallbladder, gastrointestinal, arthritis, and osteoporosis) and conditions (high blood pressure, elevated cholesterol level). Height and weight were measured at baseline. Participants were followed for a median of 7.3 years (range 0.8-15.0). Cox regression analysis was performed to assess whether comorbidities predicted disease-free and overall survival; hazard ratio (HR) was the measure of association. Overall, there were 406 additional breast cancer events and 242 deaths. Participants with diabetes had over twofold the risk of additional breast cancer events (HR 2.1, 95% CI: 1.3, 3.4) and mortality (HR 2.5, 95% CI: 1.4, 4.4). The presence of multiple comorbidities did not statistically significantly predict additional breast cancer events. However, compared to no comorbidities, participants with 3 or more comorbidities had a HR of 2.1, 95% CI: 1.3, 3.3 for mortality. In conclusion, type 2 diabetes is associated with poor breast cancer prognosis. Given that 85% of deaths were caused by breast cancer, these findings suggest that multiple comorbidities may reduce the likelihood of surviving additional breast cancer events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.