ArticleThe EMBO journal2010
Evidence for a protein tether involved in somatic touch.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 93 citations in OpenAlex.
- Lamellar Schwann cells in the Pacinian corpuscle potentiate vibration perception.Science advances · 2025Article
- The mechanosensitive channel ELKIN1 regulates cellular adaptations to simulated microgravity.NPJ microgravity · 2025Article
- The inner core enables transient touch detection in the Pacinian corpuscle.Science advances · 2025Article
- In vivo calcium imaging reveals directional sensitivity of C-low threshold mechanoreceptors.The Journal of physiology · 2025Article
- C. elegans touch receptor neurons direct mechanosensory complex organization via repurposing conserved basal lamina proteins.Current biology : CB · 2024Article
- A helping hand: roles for accessory cells in the sense of touch across species.Frontiers in cellular neuroscience · 2024Review
- 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle.Science advances · 2023Article
- Potentiation of PIEZO2 mechanically-activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity.Acta pharmaceutica Sinica. B · 2023Article
- Article
- The structure of sensory afferent compartments in health and disease.Journal of anatomy · 2022Review
- Psoriasis, Is It a Microdamage of Our "Sixth Sense"? A Neurocentric View.International journal of molecular sciences · 2022Article
- CD3International journal of molecular sciences · 2022Article
- Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation.Biomolecules · 2022Review
- Physics of mechanotransduction by Piezo ion channels.The Journal of general physiology · 2022Review
- Molecular determinants of mechanosensation in the muscle spindle.Current opinion in neurobiology · 2022Review
- Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels.Frontiers in cell and developmental biology · 2022Review
- The mechanosensory neurons of touch and their mechanisms of activation.Nature reviews. Neuroscience · 2021Review
- The Form and Function of PIEZO2.Annual review of biochemistry · 2021Review
- USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans.Nature neuroscience · 2021Article
- Role of microtubules in Piezo2 mechanotransduction of mouse Merkel cells.Journal of neurophysiology · 2020Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gating of ion channels by mechanical force underlies the sense of touch and pain. The mode of gating of mechanosensitive ion channels in vertebrate touch receptors is unknown. Here we show that the presence of a protein link is necessary for the gating of mechanosensitive currents in all low-threshold mechanoreceptors and some nociceptors of the dorsal root ganglia (DRG). Using TEM, we demonstrate that a protein filament with of length approximately 100 nm is synthesized by sensory neurons and may link mechanosensitive ion channels in sensory neurons to the extracellular matrix. Brief treatment of sensory neurons with non-specific and site-specific endopeptidases destroys the protein tether and abolishes mechanosensitive currents in sensory neurons without affecting electrical excitability. Protease-sensitive tethers are also required for touch-receptor function in vivo. Thus, unlike the majority of nociceptors, cutaneous mechanoreceptors require a distinct protein tether to transduce mechanical stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.