Evidence map›Paper›PMID 20075759›Full record

ReviewPediatric research2010

DNA diagnostics: nanotechnology-enhanced electrochemical detection of nucleic acids.

Fang Wei, Peter B Lillehoj, Chih-Ming Ho

Abstract readReview
In one paragraph

Review in Pediatric research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Electrochemical Sensors for Detection of Phytomolecules: A Mechanistic Approach.Combinatorial chemistry & high throughput screening · 2024
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Hydrogel-Based Biosensors.Gels (Basel, Switzerland) · 2022
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Advanced DNA DetectionFrontiers in bioengineering and biotechnology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fang WeiMechanical and Aerospace Engineering Department, School of Engineering and Applied Science, University of California, Los Angeles, California 90095, USA.
Peter B Lillehoj
Chih-Ming Ho

Funding

The Center for Systemic Control of Cyto-NetworksPN2EY018228 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HO, CHIH-MING · 2006 to 2010
$8.2M
Oral Fluid NanoSensor Test (OFNASET)U01DE017790 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2006 to 2010
$7.3M
UCLA FUNDAMENTAL CLINICAL RESEARCH TRAINING PROGRAMT32DE007296 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 1996 to 2011
$5.8M
NEI NIH HHS PN2 EY018228NIDCR NIH HHS DE007296NIDCR NIH HHS T32 DE007296NIDCR NIH HHS U01 DE017790NIDCR NIH HHS U01DE017790
6 · The paper itself

Abstract

The detection of mismatched base pairs in DNA plays a crucial role in the diagnosis of genetic-related diseases and conditions, especially for early stage treatment. Among the various biosensors that have been used for DNA detection, EC sensors show great promise because they are capable of precise DNA recognition and efficient signal transduction. Advancements in micro- and nanotechnologies, specifically fabrication techniques and new nanomaterials, have enabled for the development of highly sensitive, highly specific sensors making them attractive for the detection of small sequence variations. Furthermore, the integration of sensors with sample preparation and fluidic processes enables for rapid, multiplexed DNA detection essential for POC clinical diagnostics.

Indexed as

Electrochemical TechniquesGenetic TestingNanotechnologyBiosensing TechniquesDNADNA Mutational AnalysisEquipment DesignGenetic Predisposition to DiseaseHumansNanomedicinePoint-of-Care SystemsPredictive Value of TestsSensitivity and SpecificityDNA

Identifiers

PMID20075759
PMCPMC2876983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.