ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2010
Unique features of animal mitochondrial translation systems. The non-universal genetic code, unusual features of the translational apparatus and their relevance to human mitochondrial diseases.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed.
- Complete Mitochondrial Genome of the Araucanian Herring,Ecology and evolution · 2025Article
- The mechanism of dynamic steady states in lamellipodia.PLoS computational biology · 2025Article
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- Molecular basis of human nuclear and mitochondrial tRNA 3' processing.Nature structural & molecular biology · 2025Article
- Structural basis of 3'-tRNA maturation by the human mitochondrial RNase Z complex.The EMBO journal · 2024Article
- The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues.NAR cancer · 2024Review
- Incompatibility and Interchangeability in Molecular Evolution.Genome biology and evolution · 2023Review
- Evolution: Mitochondrial Ribosomes Across Species.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson's disease by highlighting the use of cybrid models.Cellular and molecular life sciences : CMLS · 2022Review
- Article
- The Evolutionary Fate of Mitochondrial Aminoacyl-tRNA Synthetases in Amitochondrial Organisms.Journal of molecular evolution · 2021Article
- Hopeful monsters: unintended sequencing of famously malformed mite mitochondrial tRNAs reveals widespread expression and processing of sense-antisense pairs.NAR genomics and bioinformatics · 2021Article
- Review
- Homoplasmic mitochondrial tRNANeurology. Genetics · 2020Article
- Naturally Occurring tRNAs With Non-canonical Structures.Frontiers in microbiology · 2020Review
- Review
- Dynamic association of human mRNP proteins with mitochondrial tRNAs in the cytosol.RNA (New York, N.Y.) · 2018Article
- Small but large enough: structural properties of armless mitochondrial tRNAs from the nematode Romanomermis culicivorax.Nucleic acids research · 2018Article
- The mitochondrial epitranscriptome: the roles of RNA modifications in mitochondrial translation and human disease.Cellular and molecular life sciences : CMLS · 2018Review
- Novel AARS2 gene mutation producing leukodystrophy: a case report.Journal of human genetics · 2017Article
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Abstract
In animal mitochondria, several codons are non-universal and their meanings differ depending on the species. In addition, the tRNA structures that decipher codons are sometimes unusually truncated. These features seem to be related to the shortening of mitochondrial (mt) genomes, which occurred during the evolution of mitochondria. These organelles probably originated from the endosymbiosis of an aerobic eubacterium into an ancestral eukaryote. It is plausible that these events brought about the various characteristic features of animal mt translation systems, such as genetic code variations, unusually truncated tRNA and rRNA structures, unilateral tRNA recognition mechanisms by aminoacyl-tRNA synthetases, elongation factors and ribosomes, and compensation for RNA deficits by enlarged proteins. In this article, we discuss molecular mechanisms for these phenomena. Finally, we describe human mt diseases that are caused by modification defects in mt tRNAs.
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