ArticleJournal of the National Cancer Institute2010
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
Article in Journal of the National Cancer Institute, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 128 citations in OpenAlex.
- Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Trial
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- Esophageal adenocarcinoma models: a closer look.Frontiers in molecular biosciences · 2024Review
- Integrative proteomic characterization of adenocarcinoma of esophagogastric junction.Nature communications · 2023Article
- An automated cell line authentication method for AstraZeneca global cell bank using deep neural networks on brightfield images.Scientific reports · 2022Article
- Oestrogen Receptor Isoforms May Represent a Therapeutic Target in Oesophageal Adenocarcinoma.Cancers · 2022Article
- Establishment, authenticity, and characterization of cervical cancer cell lines.Molecular & cellular oncology · 2022Review
- Do we really know how many clinical trials are conducted ethically? Why research ethics committee review practices need to be strengthened and initial steps we could take to strengthen them.Journal of medical ethics · 2021Review
- Standardization of esophageal adenocarcinoma in vitro model and its applicability for model drug testing.Scientific reports · 2021Article
- MicroRNA Profiling in Oesophageal Adenocarcinoma Cell Lines and Patient Serum Samples Reveals a Role for miR-451a in Radiation Resistance.International journal of molecular sciences · 2020Article
- GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.The Journal of pathology · 2020Article
- Rescuing Informed Consent: How the new "Key Information" and "Reasonable Person" Provisions in the Revised U.S. Common Rule open the door to long Overdue Informed Consent Disclosure Improvements and why we need to walk Through that door.Science and engineering ethics · 2020Article
- Genetic Alterations Featuring Biological Models to Tailor Clinical Management of Pancreatic Cancer Patients.Cancers · 2020Review
- Esophageal Tumor Microenvironment.Advances in experimental medicine and biology · 2020Review
- GEAMP, a novel gastroesophageal junction carcinoma cell line derived from a malignant pleural effusion.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- A novel mechanism for the anticancer activity of aspirin and salicylates.International journal of oncology · 2019Article
- Article
- Laparoscopic fluorescence image-guided photothermal therapy enhances cancer diagnosis and treatment.Nanotheranostics · 2019Article
- Evaluation genotypes of cancer cell lines HCC1954 and SiHa by short tandem repeat (STR) analysis and DNA sequencing.Molecular biology reports · 2018Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 4 countries.
Funding
Abstract
For decades, hundreds of different human tumor type-specific cell lines have been used in experimental cancer research as models for their respective tumors. The veracity of experimental results for a specific tumor type relies on the correct derivation of the cell line. In a worldwide effort, we verified the authenticity of all available esophageal adenocarcinoma (EAC) cell lines. We proved that the frequently used cell lines SEG-1 and BIC-1 and the SK-GT-5 cell line are in fact cell lines from other tumor types. Experimental results based on these contaminated cell lines have led to ongoing clinical trials recruiting EAC patients, to more than 100 scientific publications, and to at least three National Institutes of Health cancer research grants and 11 US patents, which emphasizes the importance of our findings. Widespread use of contaminated cell lines threatens the development of treatment strategies for EAC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.