ArticleJournal of biological rhythms2010
Reorganization of suprachiasmatic nucleus networks under 24-h LDLD conditions.
Article in Journal of biological rhythms, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Reorganization of circadian activity and the pacemaker circuit under novel light regimes.Proceedings. Biological sciences · 2024Article
- Extensive soma-soma plate-like contact sites (ephapses) connect suprachiasmatic nucleus neurons.The Journal of comparative neurology · 2024Article
- Synchronization, clustering, and weak chimeras in a densely coupled transcription-based oscillator model for split circadian rhythms.Chaos (Woodbury, N.Y.) · 2023Article
- Naturalistic Intensities of Light at Night: A Review of the Potent Effects of Very Dim Light on Circadian Responses and Considerations for Translational Research.Frontiers in neurology · 2021Review
- Photoperiodic Requirements for Induction and Maintenance of Rhythm Bifurcation and Extraordinary Entrainment in Male Mice.Clocks & sleep · 2019Article
- Enhanced Circadian Entrainment in Mice and Its Utility under Human Shiftwork Schedules.Clocks & sleep · 2019Article
- Exceptional Entrainment of Circadian Activity Rhythms With Manipulations of Rhythm Waveform in Male Syrian Hamsters.The Yale journal of biology and medicine · 2019Article
- Reported light in the sleep environment: enhancement of the sleep diary.Nature and science of sleep · 2019Article
- Extraordinary behavioral entrainment following circadian rhythm bifurcation in mice.Scientific reports · 2016Article
- In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms.Neuroscience · 2016Review
- Photoperiodic and circadian bifurcation theories of depression and mania.F1000Research · 2015Review
- Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency.Neuroscience · 2014Article
- The role of the circadian system in fractal neurophysiological control.Biological reviews of the Cambridge Philosophical Society · 2013Review
- Neuroanatomy of the extended circadian rhythm system.Experimental neurology · 2013Review
- Depression-like responses induced by daytime light deficiency in the diurnal grass rat (Arvicanthis niloticus).PloS one · 2013Article
- Twice daily melatonin peaks in Siberian but not Syrian hamsters under 24 h light:dark:light:dark cycles.Chronobiology international · 2012Article
- Individual differences in circadian waveform of Siberian hamsters under multiple lighting conditions.Journal of biological rhythms · 2012Article
- Orexinergic signaling mediates light-induced neuronal activation in the dorsal raphe nucleus.Neuroscience · 2012Article
- Twelve-hour days in the brain and behavior of split hamsters.The European journal of neuroscience · 2012Article
- Changing the waveform of circadian rhythms: considerations for shift-work.Frontiers in neurology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The suprachiasmatic nucleus (SCN), locus of the master circadian clock in the brain, is comprised of multioscillator neural networks that are highly plastic in responding to environmental lighting conditions. Under a 24-h light:dark:light:dark (LDLD) cycle, hamsters bifurcate their circadian locomotor activity such that wheel running occurs in each of the 2 daily dark periods with complete inactivity in between. In the present study, we explored the neural underpinning of this behavioral bifurcation. Using calbindin (CalB)- containing cells of the SCN as a regional marker, we characterized PER1 and c-FOS expression in the core and shell SCN subregions. In LD-housed animals, it is known that PER1 and c-FOS in the core and shell region are in phase with each other. In contrast, in behaviorally bifurcated animals housed in LDLD, the core and shell SCN exhibit antiphase rhythms of PER1. Furthermore, cells in the core show high FOS expression in each photophase of the LDLD cycle. The activation of FOS in the core is light driven and disappears rapidly when the photophase is replaced by darkness. The results suggest that bifurcated activity bouts in daytime and nighttime are associated with oscillating groups of cells in the core and shell subregions, respectively, and support the notion that reorganization of SCN networks underlies changes in behavioral responses under different environmental lighting conditions.
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Registered trials
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