ArticleAJNR. American journal of neuroradiology2010
Differential diagnosis of dementia with Lewy Bodies and Alzheimer Disease using combined MR imaging and brain perfusion single-photon emission tomography.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A Unified Continuous Staging Framework for Alzheimer's Disease and Lewy Body Dementia via Hierarchical Anatomical Features.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026Article
- Right anterior insula ASL hypoperfusion as a diagnostic biomarker of prodromal and mild dementia with Lewy bodies: preliminary evidence using a Bayesian approach.GeroScience · 2025Article
- Assessment of cerebral perfusion alterations in dementia with Lewy bodies and Alzheimer's disease.Quantitative imaging in medicine and surgery · 2024Article
- Differential diagnosis of MCI with Lewy bodies and MCI due to Alzheimer's disease by visual assessment of occipital hypoperfusion on SPECT images.Japanese journal of radiology · 2024Article
- The Legacy of the TTASAAN Report-Premature Conclusions and Forgotten Promises: A Review of Policy and Practice Part I.Frontiers in neurology · 2021Review
- A New Way Forward: How Brain SPECT Imaging Can Improve Outcomes and Transform Mental Health Care Into Brain Health Care.Frontiers in psychiatry · 2021Article
- Tau PET and relative cerebral blood flow in dementia with Lewy bodies: A PET study.NeuroImage. Clinical · 2020Article
- Brain perfusion in dementia with Lewy bodies and Alzheimer's disease: an arterial spin labeling MRI study on prodromal and mild dementia stages.Alzheimer's research & therapy · 2016Article
- Neuroimaging characteristics of dementia with Lewy bodies.Alzheimer's research & therapy · 2014Review
- Automatic volumetry of the cerebrospinal fluid space in idiopathic normal pressure hydrocephalus.Dementia and geriatric cognitive disorders extra · 2013Article
- Onset Patterns and Initial Symptoms of Dementia with Lewy Bodies: Possible Pathophysiological Diversities Deduced from a SPECT Study.Dementia and geriatric cognitive disorders extra · 2011Article
- Brain SPECT Imaging in Complex Psychiatric Cases: An Evidence-Based, Underutilized Tool.The open neuroimaging journal · 2011Article
- Perfusion Imaging with SPECT in the Era of Pathophysiology-Based Biomarkers for Alzheimer's Disease.International journal of Alzheimer's disease · 2010Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeDiagnostic performance by MR imaging or by SPECT alone in discriminating DLB patients from AD patients has been estimated previously. However, the performance of a combination of MR imaging and SPECT has not yet been evaluated. Our aim was to evaluate the usefulness of combining MR imaging and SPECT to discriminate mild DLB from AD. MATERIALS AND
methodsNineteen patients with mild DLB and 19 age- and cognitive decline-matched patients with mild AD underwent both SPECT and MR imaging. Hippocampal, occipital, and striatal volume and SPECT count ratios were compared. Linear discriminant and ROC analyses were performed by using the parameters of striatal volume and the occipital SPECT ratio.
resultsThe striatal volume ratio in the DLB group was significantly lower than that in the AD group. The occipital SPECT ratio in the DLB group was lower than that in the AD group. The mean area under the ROC curve from combined MR imaging and SPECT (AUC = 0.898) was higher than that from MR imaging (AUC = 0.679) or SPECT (AUC = 0.798) alone.
conclusionsBy combining MR imaging and SPECT, we were able to distinguish patients with mild DLB from those with AD with a high level of accuracy. Our findings suggest that combining MR imaging and SPECT modalities is a useful and practical approach for diagnostically differentiating DLB from AD.
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