ArticleAJNR. American journal of neuroradiology2010
Occurrence and predictors of futile recanalization following endovascular treatment among patients with acute ischemic stroke: a multicenter study.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 98 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion: a Randomized, Open-label, Proof of Concept Study
Cerebral Hemodynamic Management Based on Cerebral Autoregulation Monitoring in Acute Ischemic Stroke Patients After Endovascular Treatment: a Multicenter, Open-label, Randomized Control Study
Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy: A Phase II, Randomized, Multicenter, Double-blind, Single Dose, Placebo-controlled Parallel Trial
Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion: A Phase Ⅱa,Prospective,Multicenter,Randomized, Double-blind,Placebo-controlled Parallel Trial
A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke, MODEST, Research Protocol
Effects of Y-6 Sublingual Tablets for Patients With Acute Ischemic Stroke: A Phase Ⅱ, Randomized, Double-blind, Double-dummy, Placebo-controlled Parallel Trial
FUtile Reperfusion in acuTe iscHEmic stRoke- FURTHER
Local-to-Systemic Inflammatory Biomarker Gradients and 90-Day Functional Outcomes in Patients With Acute Ischemic Stroke Due to Anterior Circulation Large Vessel Occlusion Undergoing Mechanical Thrombectomy: A Prospective Observational Cohort Study
Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it, 193 citations in OpenAlex.
- Pooled it
- Pharmacokinetics, pharmacodynamics, safety, tolerability, and mass balance of single and continuous intravenous infusion of SPT-07A in healthy volunteers.European journal of clinical pharmacology · 2020Trial
- Patient selection for mechanical thrombectomy.Clinical neuroradiology · 2014Trial
- MRI before intraarterial therapy in ischemic stroke: feasibility, impact, and safety.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Trial
- Endovascular treatment for acute ischemic stroke.The New England journal of medicine · 2013Trial
- Multimodal reperfusion therapy for large hemispheric infarcts in octogenarians: is good outcome a realistic goal?AJNR. American journal of neuroradiology · 2012Trial
- Angiographic Success Does Not Fully Reflect Tissue-Level Reperfusion: New Diffusion-Weighted Imaging Lesions After True Complete (TICI 3) Recanalization.Diagnostics (Basel, Switzerland) · 2026Article
- Multimodal CT radiomics-clinical ensemble machine learning model effectively predicts futile recanalization after endovascular treatment of acute ischemic stroke.Frontiers in neuroscience · 2026Article
- Ferroptosis and futile recanalization after mechanical thrombectomy in acute ischemic stroke: mechanisms, risk factors, predictive models and therapeutic interventions.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Admission systemic inflammatory indices and 6-month functional outcome after endovascular thrombectomy for acute ischemic stroke: an exploratory single-center cohort study.Frontiers in neurology · 2026Article
- Dual-phase CTA filling pattern is associated with reperfusion-related complications after mechanical thrombectomy in late-window anterior circulation stroke.Frontiers in medicine · 2026Article
- Predictors of Futile Recanalization after Mechanical Thrombectomy for Middle Cerebral Artery M2 Occlusion.Journal of neuroendovascular therapy · 2026Article
- EStroke and vascular neurology · 2025Article
- Infarct Location Matters: Basal Ganglia Involvement Predicts Poor Outcomes despite Successful Endovascular Thrombectomy in Large Vessel Occlusion Stroke.Neurointervention · 2025Article
- Dynamic CTA-Based Whole-Brain Arterial-Venous Collateral Assessment for Predicting Futile Recanalization in Acute Ischemic Stroke.Aging and disease · 2025Article
- Adjunctive intra-arterial thrombolysis after thrombectomy: Findings from the RITE registry.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- A minimally invasive thrombotic model to study stroke in awake mice.Nature communications · 2025Article
- Early venous filling is associated with unfavorable outcomes in acute ischemic stroke with large vessel occlusion after mechanical thrombectomy: a real-world analysis.BMC neurology · 2025Article
- Development and Validation of an Interpretable Machine Learning Model for Prediction of the Risk of Clinically Ineffective Reperfusion in Patients Following Thrombectomy for Ischemic Stroke.Therapeutics and clinical risk management · 2025Article
- Predictors of futile recanalization in nonagenarians treated with mechanical thrombectomy: a multi-center observational study.Journal of neurology · 2024Observational
38 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAlthough recanalization is the goal of thrombolysis, it is well recognized that it fails to improve outcome of acute stroke in a subset of patients. Our aim was to assess the rate of and factors associated with "futile recanalization," defined by absence of clinical benefit from recanalization, following endovascular treatment of acute ischemic stroke. MATERIALS AND
methodsData from 6 studies of acute ischemic stroke treated with mechanical and/or pharmacologic endovascular treatment were analyzed. "Futile recanalization" was defined by the occurrence of unfavorable outcome (mRS score of > or = 3 at 1-3 months) despite complete angiographic recanalization (Qureshi grade 0 or TIMI grade 3).
resultsComplete recanalization was observed in 96 of 270 patients treated with IA thrombolysis. Futile recanalization was observed in 47 (49%). In univariate analysis, patients with futile recanalization were older (73 +/- 11 versus 58 +/- 15 years, P < .0001) and had higher median initial NIHSS scores (19 versus 14, P < .0001), more frequent BA occlusion (17% versus 4%, P = .049), less frequent MCA occlusion (53% versus 76%, P = .032), and a nonsignificantly higher rate of symptomatic hemorrhagic complications (2% versus 9%, P = .2). In logistic regression analysis, futile recanalization was positively associated with age > 70 years (OR, 4.4; 95% CI, 1.9-10.5; P = .0008) and initial NIHSS score 10-19 (OR, 3.8; 95% CI, 1.7-8.4; P = .001), and initial NIHSS score > or = 20 (OR, 64.4; 95% CI, 28.8-144; P < .0001).
conclusionsFutile recanalization is a relatively common occurrence following endovascular treatment, particularly among elderly patients and those with severe neurologic deficits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.