ArticlePain2010
Central and peripheral hypersensitivity in the irritable bowel syndrome.
Article in Pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01327300 (Randomized, Double-blind, Cross-over Study of the Efficacy of Mesalamine in Diarrhea-predominant Irritable Bowel Syndrome), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Double-blind, Cross-over Study of the Efficacy of Mesalamine in Diarrhea-predominant Irritable Bowel Syndrome (dIBS)
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis.Systematic reviews · 2015Pooled it
- Comparison of electroacupuncture and moxibustion on brain-gut function in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial.Chinese journal of integrative medicine · 2015Trial
- Viscerosomatic facilitation in a subset of IBS patients, an effect mediated by N-methyl-D-aspartate receptors.The journal of pain · 2012Trial
- Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome.The journal of pain · 2011Trial
- Are Conditioned Pain Modulation and Pain Sensitivity Risk Factors for the Development of Functional Somatic Disorder? A Longitudinal Population-Based Study.European journal of pain (London, England) · 2026Article
- The Mast Cell-PAR2-TRP Axis: A Convergent Mechanism for Visceral Hypersensitivity Independent of Divergent Motility in IBS.Biomolecules · 2026Review
- Effectiveness of a FODMAP-Based, Coach-Supervised, and Peer-Supported Lifestyle Program in Reducing Gastrointestinal and Extraintestinal Symptoms in Irritable Bowel Syndrome.Gastro hep advances · 2026Article
- Irritable bowel syndrome and its impact on utilization and outcomes in elective thoracolumbar fusion.Brain & spine · 2026Article
- Altered gut microbial functional pathways in people with irritable bowel syndrome enable precision health insights.BMC gastroenterology · 2025Article
- Gastrointestinal symptoms in patients with postural orthostatic tachycardia syndrome in relation to hemodynamic findings and immunological factors.Frontiers in physiology · 2024Article
- Epigenetic modulation of visceral nociception.Neurogastroenterology and motility · 2022Review
- Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome.Journal of gastroenterology and hepatology · 2022Article
- RETRACTED: Efficacy of a Product Containing Xyloglucan and Pea Protein on Intestinal Barrier Function in a Partial Restraint Stress Animal Model.International journal of molecular sciences · 2022Article
- Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders.Frontiers in neuroscience · 2022Article
- Extraintestinal manifestations in irritable bowel syndrome: A systematic review.Therapeutic advances in gastroenterology · 2022Review
- Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1-Piezo2 Axis.Frontiers in endocrinology · 2022Article
- Conditioned pain modulation and pain sensitivity in functional somatic disorders: The DanFunD study.European journal of pain (London, England) · 2022Article
- Experimental Pain Sensitivity in Subjects with Temporomandibular Disorders and Multiple Other Chronic Pain Conditions: The OPPERA Prospective Cohort Study.Journal of oral & facial pain and headache · 2020Article
- Small-Conductance CaFrontiers in pharmacology · 2020Article
- Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics.Journal of experimental pharmacology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Previous investigations of somatic hypersensitivity in IBS patients have typically involved only a single stimulus modality, and little information exists regarding whether patterns of somatic pain perception vary across stimulus modalities within a group of patients with IBS. Therefore, the current study was designed to characterize differences in perceptual responses to a battery of noxious somatic stimuli in IBS patients compared to controls. A total of 78 diarrhea-predominant and 57 controls participated in the study. We evaluated pain threshold and tolerance and sensory and affective ratings of contact thermal, mechanical pressure, ischemic stimuli, and cold pressor stimuli. In addition to assessing perceptual responses, we also evaluated differences in neuroendocrine and cardiovascular responses to these experimental somatic pain stimuli. A subset of IBS patients demonstrated the presence of somatic hypersensitivity to thermal, ischemic, and cold pressor nociceptive stimuli. The somatic hypersensitivity in IBS patients was somatotopically organized in that the lower extremities that share viscerosomatic convergence with the colon demonstrate the greatest hypersensitivity. There were also changes in ACTH, cortisol, and systolic blood pressure in response to the ischemic pain testing in IBS patients when compared to controls. The results of this study suggest that a more widespread alteration in central pain processing in a subset of IBS patients may be present as they display hypersensitivity to heat, ischemic, and cold pressor stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.